Long non-coding RNAs: insights into functions. Export

by: Tim R. Mercer, Marcel E. Dinger, John S. Mattick

Nature reviews. Genetics, Vol. 10, No. 3. (3 March 2009), pp. 155-159.

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Abstract

In mammals and other eukaryotes most of the genome is transcribed in a developmentally regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we review the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome and their roles in gene regulation. We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an intrinsic function as an RNA.

@article{citeulike:4067538, abstract = {In mammals and other eukaryotes most of the genome is transcribed in a developmentally regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we review the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome and their roles in gene regulation. We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an intrinsic function as an RNA.}, author = {Mercer, Tim R. and Dinger, Marcel E. and Mattick, John S.}, citeulike-article-id = {4067538}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2521}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2521}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19188922}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19188922}, day = {3}, doi = {10.1038/nrg2521}, issn = {1471-0064}, journal = {Nature reviews. Genetics}, keywords = {lncrna, review}, month = {March}, number = {3}, pages = {155--159}, posted-at = {2009-02-18 19:32:55}, priority = {0}, title = {Long non-coding RNAs: insights into functions.}, url = {http://dx.doi.org/10.1038/nrg2521}, volume = {10}, year = {2009} }

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TY - JOUR ID - citeulike:4067538 L3 - citeulike-article-id:4067538 N2 - In mammals and other eukaryotes most of the genome is transcribed in a developmentally regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we review the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome and their roles in gene regulation. We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an intrinsic function as an RNA. IS - 3 JF - Nature reviews. Genetics SN - 1471-0064 EP - 159 TI - Long non-coding RNAs: insights into functions. VL - 10 SP - 155 KW - lncrna KW - review AU - Mercer, Tim AU - Dinger, Marcel AU - Mattick, John PY - 2009/03/03/ UR - http://dx.doi.org/10.1038/nrg2521 ER -

Long non-coding RNAs: insights into functions. Export

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