Sepsis: the dark side of histones Export

@article{citeulike:6083178, abstract = {Injection of activated protein C (APC) is the last resort to rescue a patient with severe sepsis. Research into how APC works reveals that the drug inactivates histones (pages 1318–1321), which are toxic during severe sepsis. Histones are not generally considered to be noxious; after all, they form the core around which DNA is wrapped in eukaryotes. Not only do these proteins have this essential architectural role, but also their modification is one of the key mechanisms for gene regulation.}, author = {Chaput, Catherine and Zychlinsky, Arturo}, citeulike-article-id = {6083178}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nm1109-1245}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nm1109-1245}, day = {01}, doi = {10.1038/nm1109-1245}, issn = {1078-8956}, journal = {Nature Medicine}, keywords = {histone}, month = {November}, number = {11}, pages = {1245--1246}, posted-at = {2009-11-07 17:57:13}, priority = {2}, publisher = {Nature Publishing Group}, title = {Sepsis: the dark side of histones}, url = {http://dx.doi.org/10.1038/nm1109-1245}, volume = {15}, year = {2009} }

TY - JOUR ID - citeulike:6083178 L3 - citeulike-article-id:6083178 N2 - Injection of activated protein C (APC) is the last resort to rescue a patient with severe sepsis. Research into how APC works reveals that the drug inactivates histones (pages 1318–1321), which are toxic during severe sepsis. Histones are not generally considered to be noxious; after all, they form the core around which DNA is wrapped in eukaryotes. Not only do these proteins have this essential architectural role, but also their modification is one of the key mechanisms for gene regulation. IS - 11 JF - Nature Medicine SN - 1078-8956 EP - 1246 TI - Sepsis: the dark side of histones PB - Nature Publishing Group VL - 15 SP - 1245 KW - histone AU - Chaput, Catherine AU - Zychlinsky, Arturo PY - 2009/11/01/ UR - http://dx.doi.org/10.1038/nm1109-1245 ER -