A genome-wide association study identifies novel risk loci for type 2 diabetes. Export

@article{citeulike:1104572, abstract = {Type 2 diabetes mellitus results from the interaction of environmental factors with a combination of genetic variants, most of which were hitherto unknown. A systematic search for these variants was recently made possible by the development of high-density arrays that permit the genotyping of hundreds of thousands of polymorphisms. We tested 392,935 single-nucleotide polymorphisms in a French case-control cohort. Markers with the most significant difference in genotype frequencies between cases of type 2 diabetes and controls were fast-tracked for testing in a second cohort. This identified four loci containing variants that confer type 2 diabetes risk, in addition to confirming the known association with the TCF7L2 gene. These loci include a non-synonymous polymorphism in the zinc transporter SLC30A8, which is expressed exclusively in insulin-producing beta-cells, and two linkage disequilibrium blocks that contain genes potentially involved in beta-cell development or function (IDE-KIF11-HHEX and EXT2-ALX4). These associations explain a substantial portion of disease risk and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.}, author = {Sladek, Robert and Rocheleau, Ghislain and Rung, Johan and Dina, Christian and Shen, Lishuang and Serre, David and Boutin, Philippe and Vincent, Daniel and Belisle, Alexandre and Hadjadj, Samy and Balkau, Beverley and Heude, Barbara and Charpentier, Guillaume and Hudson, Thomas J. and Montpetit, Alexandre and Pshezhetsky, Alexey V. and Prentki, Marc and Posner, Barry I. and Balding, David J. and Meyre, David and Polychronakos, Constantin and Froguel, Philippe}, citeulike-article-id = {1104572}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature05616}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature05616}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17293876}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17293876}, day = {22}, doi = {10.1038/nature05616}, issn = {1476-4687}, journal = {Nature}, keywords = {association, gwa}, month = {February}, number = {7130}, pages = {881--885}, posted-at = {2009-01-18 15:04:11}, priority = {0}, publisher = {Nature Publishing Group}, title = {A genome-wide association study identifies novel risk loci for type 2 diabetes.}, url = {http://dx.doi.org/10.1038/nature05616}, volume = {445}, year = {2007} }

TY - JOUR ID - citeulike:1104572 L3 - citeulike-article-id:1104572 N2 - Type 2 diabetes mellitus results from the interaction of environmental factors with a combination of genetic variants, most of which were hitherto unknown. A systematic search for these variants was recently made possible by the development of high-density arrays that permit the genotyping of hundreds of thousands of polymorphisms. We tested 392,935 single-nucleotide polymorphisms in a French case-control cohort. Markers with the most significant difference in genotype frequencies between cases of type 2 diabetes and controls were fast-tracked for testing in a second cohort. This identified four loci containing variants that confer type 2 diabetes risk, in addition to confirming the known association with the TCF7L2 gene. These loci include a non-synonymous polymorphism in the zinc transporter SLC30A8, which is expressed exclusively in insulin-producing beta-cells, and two linkage disequilibrium blocks that contain genes potentially involved in beta-cell development or function (IDE-KIF11-HHEX and EXT2-ALX4). These associations explain a substantial portion of disease risk and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits. IS - 7130 JF - Nature SN - 1476-4687 EP - 885 TI - A genome-wide association study identifies novel risk loci for type 2 diabetes. PB - Nature Publishing Group VL - 445 SP - 881 KW - association KW - gwa AU - Sladek, Robert AU - Rocheleau, Ghislain AU - Rung, Johan AU - Dina, Christian AU - Shen, Lishuang AU - Serre, David AU - Boutin, Philippe AU - Vincent, Daniel AU - Belisle, Alexandre AU - Hadjadj, Samy AU - Balkau, Beverley AU - Heude, Barbara AU - Charpentier, Guillaume AU - Hudson, Thomas AU - Montpetit, Alexandre AU - Pshezhetsky, Alexey AU - Prentki, Marc AU - Posner, Barry AU - Balding, David AU - Meyre, David AU - Polychronakos, Constantin AU - Froguel, Philippe PY - 2007/02/22/ UR - http://dx.doi.org/10.1038/nature05616 ER -