Effects of dominance on the probability of fixation of a mutant allele Export

@article{citeulike:2075595, abstract = {Abstract\ \ We consider whether the fixation probability of an allele in a two-allele diploid system is always a monotonic function of the selective advantage of the allele. We show that while this conjecture is correct for intermediate dominance, it is not correct in general for either overdominant or underdominant alleles, and that for some parameter ranges the fixation probability can initially decrease and then increase as a function of the amount of selection. We have partial results that characterize the ranges of parameters for which this happens.}, author = {Chen, Christina and Chi, Quo-Shin and Sawyer, Stanley}, citeulike-article-id = {2075595}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00285-007-0121-7}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17710402}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17710402}, day = {3}, doi = {10.1007/s00285-007-0121-7}, journal = {Journal of Mathematical Biology}, keywords = {dominance, fixationprob, selection}, month = {March}, number = {3}, pages = {413--434}, posted-at = {2009-01-18 19:37:12}, priority = {3}, title = {Effects of dominance on the probability of fixation of a mutant allele}, url = {http://dx.doi.org/10.1007/s00285-007-0121-7}, volume = {56}, year = {2008} }

TY - JOUR ID - citeulike:2075595 L3 - citeulike-article-id:2075595 N2 - Abstract  We consider whether the fixation probability of an allele in a two-allele diploid system is always a monotonic function of the selective advantage of the allele. We show that while this conjecture is correct for intermediate dominance, it is not correct in general for either overdominant or underdominant alleles, and that for some parameter ranges the fixation probability can initially decrease and then increase as a function of the amount of selection. We have partial results that characterize the ranges of parameters for which this happens. IS - 3 JF - Journal of Mathematical Biology EP - 434 TI - Effects of dominance on the probability of fixation of a mutant allele VL - 56 SP - 413 KW - dominance KW - fixationprob KW - selection AU - Chen, Christina AU - Chi, Quo-Shin AU - Sawyer, Stanley PY - 2008/03/03/ UR - http://dx.doi.org/10.1007/s00285-007-0121-7 ER -