The coalescent process and background selection. Export

@article{citeulike:3906004, abstract = {Some statistical properties of gene trees are described for a model with background deleterious mutations. It is argued that the history of a small sample of genes under this model is a continuous time Markov chain that quickly reaches stationarity. This observation leads to simple expressions for the expected nucleotide diversity and suggests that the frequency spectrum in small samples should be approximately the same as under a strict neutral model. The results concerning expected nucleotide diversity are compared with observed variation on the third chromosome of Drosophila melanogaster.}, author = {Hudson, R. R. and Kaplan, N. L.}, citeulike-article-id = {3906004}, citeulike-linkout-0 = {http://dx.doi.org/10.1098/rstb.1995.0086}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/8748015}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=8748015}, day = {29}, doi = {10.1098/rstb.1995.0086}, issn = {0962-8436}, journal = {Philosophical transactions of the Royal Society of London. Series B, Biological sciences}, keywords = {backgroundselection, coalescent, genealogy, selectiondnds}, month = {July}, number = {1327}, pages = {19--23}, posted-at = {2009-01-18 12:29:01}, priority = {0}, title = {The coalescent process and background selection.}, url = {http://dx.doi.org/10.1098/rstb.1995.0086}, volume = {349}, year = {1995} }

TY - JOUR ID - citeulike:3906004 L3 - citeulike-article-id:3906004 N2 - Some statistical properties of gene trees are described for a model with background deleterious mutations. It is argued that the history of a small sample of genes under this model is a continuous time Markov chain that quickly reaches stationarity. This observation leads to simple expressions for the expected nucleotide diversity and suggests that the frequency spectrum in small samples should be approximately the same as under a strict neutral model. The results concerning expected nucleotide diversity are compared with observed variation on the third chromosome of Drosophila melanogaster. IS - 1327 JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences SN - 0962-8436 EP - 23 TI - The coalescent process and background selection. VL - 349 SP - 19 KW - backgroundselection KW - coalescent KW - genealogy KW - selectiondnds AU - Hudson, RR AU - Kaplan, NL PY - 1995/07/29/ UR - http://dx.doi.org/10.1098/rstb.1995.0086 ER -