A test of neutral molecular evolution based on nucleotide data. Export

@article{citeulike:785184, abstract = {The neutral theory of molecular evolution predicts that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of polymorphism within species. We present here a conservative statistical test of this prediction based on a constant-rate neutral model. The test requires data from an interspecific comparison of at least two regions of the genome and data on levels of intraspecific polymorphism in the same regions from at least one species. The model is rejected for data from the region encompassing the Adh locus and the 5' flanking sequence of Drosophila melanogaster and Drosophila sechellia. The data depart from the model in a direction that is consistent with the presence of balanced polymorphism in the coding region.}, author = {Hudson, R. R. and Kreitman, M. and Aguad\'{e}, M.}, citeulike-article-id = {785184}, citeulike-linkout-0 = {http://www.genetics.org/cgi/content/abstract/116/1/153}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/3110004}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=3110004}, day = {1}, issn = {0016-6731}, journal = {Genetics}, keywords = {hka, selection}, month = {May}, number = {1}, pages = {153--159}, posted-at = {2009-01-17 12:59:53}, priority = {2}, title = {A test of neutral molecular evolution based on nucleotide data.}, url = {http://www.genetics.org/cgi/content/abstract/116/1/153}, volume = {116}, year = {1987} }

TY - JOUR ID - citeulike:785184 L3 - citeulike-article-id:785184 N2 - The neutral theory of molecular evolution predicts that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of polymorphism within species. We present here a conservative statistical test of this prediction based on a constant-rate neutral model. The test requires data from an interspecific comparison of at least two regions of the genome and data on levels of intraspecific polymorphism in the same regions from at least one species. The model is rejected for data from the region encompassing the Adh locus and the 5' flanking sequence of Drosophila melanogaster and Drosophila sechellia. The data depart from the model in a direction that is consistent with the presence of balanced polymorphism in the coding region. IS - 1 JF - Genetics SN - 0016-6731 EP - 159 TI - A test of neutral molecular evolution based on nucleotide data. VL - 116 SP - 153 KW - hka KW - selection AU - Hudson, RR AU - Kreitman, M AU - Aguadé, M PY - 1987/05/01/ UR - http://www.genetics.org/cgi/content/abstract/116/1/153 ER -