Interrogating a High-Density SNP Map for Signatures of Natural Selection Export

@article{citeulike:797148, abstract = {10.1101/gr.631202 Identifying genomic regions that have been targets of natural selection remains one of the most important and challenging areas of research in genetics. To this end, we report an analysis of 26,530 single nucleotide polymorphisms (SNPs) with allele frequencies that were determined in three populations. Specifically, we calculated a measure of genetic differentiation, F, for each locus and examined its distribution at the level of the genome, the chromosome, and individual genes. Through a variety of analyses, we have found statistically significant evidence supporting the hypothesis that selection has influenced extant patterns of human genetic variation. Importantly, by contrasting the F of individual SNPs to the empirical genome-wide distribution of F, our results are not confounded by tenuous assumptions of population demographic history. Furthermore, we have identified 174 candidate genes with distribution of genetic variation that indicates that they have been targets of selection. Our work provides a first generation natural selection map of the human genome and provides compelling evidence that selection has shaped extant patterns of human genomic variation. [Supplemental material is available online at.]}, address = {Center for Genome Information, University of Cincinnati, Cincinnati, Ohio, USA.}, author = {Akey, Joshua M. and Zhang, Ge and Zhang, Kun and Jin, Li and Shriver, Mark D.}, citeulike-article-id = {797148}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gr.631202}, citeulike-linkout-1 = {http://genome.cshlp.org/content/12/12/1805.abstract}, citeulike-linkout-2 = {http://genome.cshlp.org/content/12/12/1805.full.pdf}, citeulike-linkout-3 = {http://www.genome.org/cgi/content/abstract/12/12/1805}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/12466284}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=12466284}, day = {1}, doi = {10.1101/gr.631202}, issn = {1088-9051}, journal = {Genome Research}, keywords = {fst, genome, genomescan}, month = {December}, number = {12}, pages = {1805--1814}, posted-at = {2009-01-18 08:29:18}, priority = {0}, title = {Interrogating a High-Density SNP Map for Signatures of Natural Selection}, url = {http://dx.doi.org/10.1101/gr.631202}, volume = {12}, year = {2002} }

TY - JOUR ID - citeulike:797148 L3 - citeulike-article-id:797148 N2 - 10.1101/gr.631202 Identifying genomic regions that have been targets of natural selection remains one of the most important and challenging areas of research in genetics. To this end, we report an analysis of 26,530 single nucleotide polymorphisms (SNPs) with allele frequencies that were determined in three populations. Specifically, we calculated a measure of genetic differentiation, F, for each locus and examined its distribution at the level of the genome, the chromosome, and individual genes. Through a variety of analyses, we have found statistically significant evidence supporting the hypothesis that selection has influenced extant patterns of human genetic variation. Importantly, by contrasting the F of individual SNPs to the empirical genome-wide distribution of F, our results are not confounded by tenuous assumptions of population demographic history. Furthermore, we have identified 174 candidate genes with distribution of genetic variation that indicates that they have been targets of selection. Our work provides a first generation natural selection map of the human genome and provides compelling evidence that selection has shaped extant patterns of human genomic variation. [Supplemental material is available online at.] IS - 12 JF - Genome Research SN - 1088-9051 AD - Center for Genome Information, University of Cincinnati, Cincinnati, Ohio, USA. EP - 1814 TI - Interrogating a High-Density SNP Map for Signatures of Natural Selection VL - 12 SP - 1805 KW - fst KW - genome KW - genomescan AU - Akey, Joshua AU - Zhang, Ge AU - Zhang, Kun AU - Jin, Li AU - Shriver, Mark PY - 2002/12/01/ UR - http://dx.doi.org/10.1101/gr.631202 ER -