The post-operative analgesic effects of a combination of gabapentin and paracetamol in patients undergoing abdominal hysterectomy: a randomized clinical trial Export

@article{citeulike:1124511, abstract = {BACKGROUND: The aim of the present study was to compare the effects of a combination of gabapentin and paracetamol with gabapentin alone and placebo on post-operative pain and morphine consumption. METHODS: Seventy-five ASA I-II patients undergoing abdominal hysterectomy were included in the study and randomly divided into three groups. Placebo capsules (Group I, n = 25), 1200 mg of gabapentin (Group II, n = 25), or 1200 mg of gabapentin and 20 mg/kg paracetamol in combination (Group III, n = 25) were administered 1 h prior to surgery. Anaesthesia was standardized for all patients. Non-invasive arterial pressure, heart rate, respiratory rate, peripheral oxygen saturation, morphine consumption, nausea and vomiting, visual analogue scale-pain intensity scores (VAS-PI) and sedation scores were recorded at 1, 2, 4, 6 and 24 h following the operation. RESULTS: Morphine consumption at 24 h was 66.60 +/- 11.49 mg, 42.74 +/- 12.33 mg and 30.50 +/- 11.55 mg, respectively, in groups I, II and III (P < 0.05). Post-operative VAS-PI scores at movement and at rest were decreased with gabapentin and even more with a combination of gabapentin and paracetamol. Post-operative sedation scores were higher in groups II and III during the initial 4 h while these scores were higher in group I at 24 h. CONCLUSIONS: The single dose of gabapentin as well as a combination of gabapentin and paracetamol decreased the opioid requirement and increased the patients' satisfaction post-operatively.}, address = {Department of Anaesthesiology, Inonu University, School of Medicine, Malatya, Turkey}, author = {Durmus and Kadirbut and Saricicek and Ilksentoprak and Ozcanersoy}, citeulike-article-id = {1124511}, citeulike-linkout-0 = {http://www.blackwell-synergy.com/doi/abs/10.1111/j.1399-6576.2006.01237.x}, citeulike-linkout-1 = {http://dx.doi.org/10.1111/j.1399-6576.2006.01237.x}, citeulike-linkout-2 = {http://www.ingentaconnect.com/content/mksg/aas/2007/00000051/00000003/art00006}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/118481117/ABSTRACT}, doi = {10.1111/j.1399-6576.2006.01237.x}, issn = {1399-6576}, journal = {Acta Anaesthesiologica Scandinavica}, keywords = {acute-pain, gabapentin, paracetamol}, month = {March}, number = {3}, pages = {299--304}, posted-at = {2008-03-16 11:56:49}, priority = {2}, publisher = {Blackwell Publishing}, title = {The post-operative analgesic effects of a combination of gabapentin and paracetamol in patients undergoing abdominal hysterectomy: a randomized clinical trial}, url = {http://dx.doi.org/10.1111/j.1399-6576.2006.01237.x}, volume = {51}, year = {2007} }

TY - JOUR ID - citeulike:1124511 L3 - citeulike-article-id:1124511 N2 - BACKGROUND: The aim of the present study was to compare the effects of a combination of gabapentin and paracetamol with gabapentin alone and placebo on post-operative pain and morphine consumption. METHODS: Seventy-five ASA I-II patients undergoing abdominal hysterectomy were included in the study and randomly divided into three groups. Placebo capsules (Group I, n = 25), 1200 mg of gabapentin (Group II, n = 25), or 1200 mg of gabapentin and 20 mg/kg paracetamol in combination (Group III, n = 25) were administered 1 h prior to surgery. Anaesthesia was standardized for all patients. Non-invasive arterial pressure, heart rate, respiratory rate, peripheral oxygen saturation, morphine consumption, nausea and vomiting, visual analogue scale-pain intensity scores (VAS-PI) and sedation scores were recorded at 1, 2, 4, 6 and 24 h following the operation. RESULTS: Morphine consumption at 24 h was 66.60 +/- 11.49 mg, 42.74 +/- 12.33 mg and 30.50 +/- 11.55 mg, respectively, in groups I, II and III (P < 0.05). Post-operative VAS-PI scores at movement and at rest were decreased with gabapentin and even more with a combination of gabapentin and paracetamol. Post-operative sedation scores were higher in groups II and III during the initial 4 h while these scores were higher in group I at 24 h. CONCLUSIONS: The single dose of gabapentin as well as a combination of gabapentin and paracetamol decreased the opioid requirement and increased the patients' satisfaction post-operatively. IS - 3 JF - Acta Anaesthesiologica Scandinavica SN - 1399-6576 AD - Department of Anaesthesiology, Inonu University, School of Medicine, Malatya, Turkey EP - 304 TI - The post-operative analgesic effects of a combination of gabapentin and paracetamol in patients undergoing abdominal hysterectomy: a randomized clinical trial PB - Blackwell Publishing VL - 51 SP - 299 KW - acute-pain KW - gabapentin KW - paracetamol AU - Durmus AU - Kadirbut AU - Saricicek AU - Ilksentoprak AU - Ozcanersoy PY - 2007/03// UR - http://dx.doi.org/10.1111/j.1399-6576.2006.01237.x ER -