Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima Export

@article{citeulike:5800877, abstract = {Metabolic pathways have traditionally been described in terms of biochemical reactions and metabolites. With the use of structural genomics and systems biology, we generated a three-dimensional reconstruction of the central metabolic network of the bacterium Thermotoga maritima. The network encompassed 478 proteins, of which 120 were determined by experiment and 358 were modeled. Structural analysis revealed that proteins forming the network are dominated by a small number (only 182) of basic shapes (folds) performing diverse but mostly related functions. Most of these folds are already present in the essential core (\~{}30\%) of the network, and its expansion by nonessential proteins is achieved with relatively few additional folds. Thus, integration of structural data with networks analysis generates insight into the function, mechanism, and evolution of biological networks. 10.1126/science.1174671}, author = {Zhang, Ying and Thiele, Ines and Weekes, Dana and Li, Zhanwen and Jaroszewski, Lukasz and Ginalski, Krzysztof and Deacon, Ashley M. and Wooley, John and Lesley, Scott A. and Wilson, Ian A. and Palsson, Bernhard and Osterman, Andrei and Godzik, Adam}, citeulike-article-id = {5800877}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1174671}, citeulike-linkout-1 = {http://www.sciencemag.org/content/325/5947/1544.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/325/5947/1544.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/325/5947/1544}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19762644}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19762644}, day = {18}, doi = {10.1126/science.1174671}, journal = {Science}, keywords = {biochemical, embedding, fold, metabolic\_pathways, networks, protrel, structure, viz}, month = {September}, number = {5947}, pages = {1544--1549}, posted-at = {2009-10-01 09:55:42}, priority = {2}, title = {Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima}, url = {http://dx.doi.org/10.1126/science.1174671}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5800877 L3 - citeulike-article-id:5800877 N2 - Metabolic pathways have traditionally been described in terms of biochemical reactions and metabolites. With the use of structural genomics and systems biology, we generated a three-dimensional reconstruction of the central metabolic network of the bacterium Thermotoga maritima. The network encompassed 478 proteins, of which 120 were determined by experiment and 358 were modeled. Structural analysis revealed that proteins forming the network are dominated by a small number (only 182) of basic shapes (folds) performing diverse but mostly related functions. Most of these folds are already present in the essential core (~30%) of the network, and its expansion by nonessential proteins is achieved with relatively few additional folds. Thus, integration of structural data with networks analysis generates insight into the function, mechanism, and evolution of biological networks. 10.1126/science.1174671 IS - 5947 JF - Science EP - 1549 TI - Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima VL - 325 SP - 1544 KW - biochemical KW - embedding KW - fold KW - metabolic_pathways KW - networks KW - protrel KW - structure KW - viz AU - Zhang, Ying AU - Thiele, Ines AU - Weekes, Dana AU - Li, Zhanwen AU - Jaroszewski, Lukasz AU - Ginalski, Krzysztof AU - Deacon, Ashley AU - Wooley, John AU - Lesley, Scott AU - Wilson, Ian AU - Palsson, Bernhard AU - Osterman, Andrei AU - Godzik, Adam PY - 2009/09/18/ UR - http://dx.doi.org/10.1126/science.1174671 ER -