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The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases Export

Chemistry & Biology, Vol. 6, No. 12. (December 1999), pp. R319-R325.

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betabranch nrps pks

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Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze chain elongation from simple building blocks to create a diverse array of natural products. PKS and NRPS proteins share striking architectural and organizational similarities that can be exploited to generate entirely new natural products.


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