Proteomic analysis of human papillomavirus-related oral squamous cell carcinoma: Identification of thioredoxin and epidermal-fatty acid binding protein as upregulated protein markers in microdissected tumor tissue. Export

@article{citeulike:4304381, abstract = {Human papillomavirus (HPV) infection has been identified as an etiologic agent for a subset of oral squamous cell carcinoma (OSCC) with increasing incidence. HPV DNA-positivity may confer better prognosis but the related oncogenic mechanisms are unknown. For the identification of HPV relevant proteins, we analyzed microdissected cells from HPV DNA-positive (n = 17) and HPV DNA-negative (n = 7) OSCC tissue samples. We identified 18 proteins from tumor tissues by peptide fingerprint mapping and SELDI MS that were separated using 2-DE. Among a number of signals that were detected as significantly different in the protein profiling analysis, we identified thioredoxin (TRX) and epidermal-fatty acid binding protein as upregulated in HPV related tumor tissue. This study, investigating for the first time proteomic changes in microdissected HPV infected tumor tissue, provides an indication on the oncogenic potential of viruses.}, author = {Melle, Christian and Ernst, G\"{u}nther and Winkler, Robert and Schimmel, Bettina and Klussmann, Jens P. and Wittekindt, Claus and Guntinas-Lichius, Orlando and von Eggeling, Ferdinand}, citeulike-article-id = {4304381}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/pmic.200800882}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19337991}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19337991}, day = {08}, doi = {10.1002/pmic.200800882}, issn = {1615-9861}, journal = {Proteomics}, keywords = {biomarker, cancer, proteomics}, month = {April}, number = {8}, pages = {2193--2201}, posted-at = {2009-04-13 18:16:49}, priority = {2}, title = {Proteomic analysis of human papillomavirus-related oral squamous cell carcinoma: Identification of thioredoxin and epidermal-fatty acid binding protein as upregulated protein markers in microdissected tumor tissue.}, url = {http://dx.doi.org/10.1002/pmic.200800882}, volume = {9}, year = {2009} }

TY - JOUR ID - citeulike:4304381 L3 - citeulike-article-id:4304381 N2 - Human papillomavirus (HPV) infection has been identified as an etiologic agent for a subset of oral squamous cell carcinoma (OSCC) with increasing incidence. HPV DNA-positivity may confer better prognosis but the related oncogenic mechanisms are unknown. For the identification of HPV relevant proteins, we analyzed microdissected cells from HPV DNA-positive (n = 17) and HPV DNA-negative (n = 7) OSCC tissue samples. We identified 18 proteins from tumor tissues by peptide fingerprint mapping and SELDI MS that were separated using 2-DE. Among a number of signals that were detected as significantly different in the protein profiling analysis, we identified thioredoxin (TRX) and epidermal-fatty acid binding protein as upregulated in HPV related tumor tissue. This study, investigating for the first time proteomic changes in microdissected HPV infected tumor tissue, provides an indication on the oncogenic potential of viruses. IS - 8 JF - Proteomics SN - 1615-9861 EP - 2201 TI - Proteomic analysis of human papillomavirus-related oral squamous cell carcinoma: Identification of thioredoxin and epidermal-fatty acid binding protein as upregulated protein markers in microdissected tumor tissue. VL - 9 SP - 2193 KW - biomarker KW - cancer KW - proteomics AU - Melle, Christian AU - Ernst, Günther AU - Winkler, Robert AU - Schimmel, Bettina AU - Klussmann, Jens AU - Wittekindt, Claus AU - Guntinas-Lichius, Orlando AU - von Eggeling, Ferdinand PY - 2009/04/08/ UR - http://dx.doi.org/10.1002/pmic.200800882 ER -