Comparative Genomics of Protists: New Insights into the Evolution of Eukaryotic Signal Transduction and Gene Regulation* Export

@article{citeulike:2739992, abstract = {Data from protist genomes suggest that eukaryotes show enormous variability in their gene complements, especially of genes coding regulatory proteins. Overall counts of eukaryotic signaling proteins show weak nonlinear scaling with proteome size, but individual superfamilies of signaling domains might show vast expansions in certain protists. Alteration of domain architectural complexity of signaling proteins and repeated lineage-specific reshaping of architectures might have played a major role in the emergence of new signaling interactions in different eukaryotes. Lateral transfer of various signaling domains from bacteria or from hosts, in parasites such as apicomplexans, appears to also have played a major role in the origin of new functional networks. Lineage-specific expansion of regulatory proteins, particularly of transcription factors, has played a critical role in the adaptive radiation of different protist lineages. Comparative genomics allows objective reconstruction of the ancestral conditions and subsequent diversification of several regulatory systems involved in phosphorylation, cyclic nucleotide signaling, Ubiquitin conjugation, chromatin remodeling, and posttranscriptional gene silencing.}, address = {National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA.}, author = {Anantharaman, Vivek and Iyer, Lakshminarayan M. and Aravind, L.}, citeulike-article-id = {2739992}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.micro.61.080706.093309}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.micro.61.080706.093309}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17506670}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17506670}, doi = {10.1146/annurev.micro.61.080706.093309}, issn = {0066-4227}, journal = {Annual Review of Microbiology}, keywords = {aravind, enzyme, evolution, expression, gene, inactive, regulation, signal, transduction}, number = {1}, pages = {453--475}, posted-at = {2009-09-18 22:56:09}, priority = {2}, title = {Comparative Genomics of Protists: New Insights into the Evolution of Eukaryotic Signal Transduction and Gene Regulation*}, url = {http://dx.doi.org/10.1146/annurev.micro.61.080706.093309}, volume = {61}, year = {2007} }

TY - JOUR ID - citeulike:2739992 L3 - citeulike-article-id:2739992 N2 - Data from protist genomes suggest that eukaryotes show enormous variability in their gene complements, especially of genes coding regulatory proteins. Overall counts of eukaryotic signaling proteins show weak nonlinear scaling with proteome size, but individual superfamilies of signaling domains might show vast expansions in certain protists. Alteration of domain architectural complexity of signaling proteins and repeated lineage-specific reshaping of architectures might have played a major role in the emergence of new signaling interactions in different eukaryotes. Lateral transfer of various signaling domains from bacteria or from hosts, in parasites such as apicomplexans, appears to also have played a major role in the origin of new functional networks. Lineage-specific expansion of regulatory proteins, particularly of transcription factors, has played a critical role in the adaptive radiation of different protist lineages. Comparative genomics allows objective reconstruction of the ancestral conditions and subsequent diversification of several regulatory systems involved in phosphorylation, cyclic nucleotide signaling, Ubiquitin conjugation, chromatin remodeling, and posttranscriptional gene silencing. IS - 1 JF - Annual Review of Microbiology SN - 0066-4227 AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA. EP - 475 TI - Comparative Genomics of Protists: New Insights into the Evolution of Eukaryotic Signal Transduction and Gene Regulation* VL - 61 SP - 453 KW - aravind KW - enzyme KW - evolution KW - expression KW - gene KW - inactive KW - regulation KW - signal KW - transduction AU - Anantharaman, Vivek AU - Iyer, Lakshminarayan AU - Aravind, L PY - 2007/// UR - http://dx.doi.org/10.1146/annurev.micro.61.080706.093309 ER -