Protein sectors: evolutionary units of three-dimensional structure. Export

@article{citeulike:5666464, abstract = {Proteins display a hierarchy of structural features at primary, secondary, tertiary, and higher-order levels, an organization that guides our current understanding of their biological properties and evolutionary origins. Here, we reveal a structural organization distinct from this traditional hierarchy by statistical analysis of correlated evolution between amino acids. Applied to the S1A serine proteases, the analysis indicates a decomposition of the protein into three quasi-independent groups of correlated amino acids that we term "protein sectors." Each sector is physically connected in the tertiary structure, has a distinct functional role, and constitutes an independent mode of sequence divergence in the protein family. Functionally relevant sectors are evident in other protein families as well, suggesting that they may be general features of proteins. We propose that sectors represent a structural organization of proteins that reflects their evolutionary histories.}, author = {Halabi, Najeeb and Rivoire, Olivier and Leibler, Stanislas and Ranganathan, Rama}, citeulike-article-id = {5666464}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2009.07.038}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0092867409009635}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19703402}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19703402}, day = {21}, doi = {10.1016/j.cell.2009.07.038}, issn = {1097-4172}, journal = {Cell}, keywords = {coevolution, compensatory, contact, correlation, evolution, fold, interaction, protein, structure}, month = {Aug}, number = {4}, pages = {774--786}, posted-at = {2009-09-23 19:49:40}, priority = {5}, title = {Protein sectors: evolutionary units of three-dimensional structure.}, url = {http://dx.doi.org/10.1016/j.cell.2009.07.038}, volume = {138}, year = {2009} }

TY - JOUR ID - citeulike:5666464 L3 - citeulike-article-id:5666464 N2 - Proteins display a hierarchy of structural features at primary, secondary, tertiary, and higher-order levels, an organization that guides our current understanding of their biological properties and evolutionary origins. Here, we reveal a structural organization distinct from this traditional hierarchy by statistical analysis of correlated evolution between amino acids. Applied to the S1A serine proteases, the analysis indicates a decomposition of the protein into three quasi-independent groups of correlated amino acids that we term "protein sectors." Each sector is physically connected in the tertiary structure, has a distinct functional role, and constitutes an independent mode of sequence divergence in the protein family. Functionally relevant sectors are evident in other protein families as well, suggesting that they may be general features of proteins. We propose that sectors represent a structural organization of proteins that reflects their evolutionary histories. IS - 4 JF - Cell SN - 1097-4172 EP - 786 TI - Protein sectors: evolutionary units of three-dimensional structure. VL - 138 SP - 774 KW - coevolution KW - compensatory KW - contact KW - correlation KW - evolution KW - fold KW - interaction KW - protein KW - structure AU - Halabi, Najeeb AU - Rivoire, Olivier AU - Leibler, Stanislas AU - Ranganathan, Rama PY - 2009/Aug/21/ UR - http://dx.doi.org/10.1016/j.cell.2009.07.038 ER -