Eukaryote-specific Domains in Translation Initiation Factors: Implications for Translation Regulation and Evolution of the Translation System TeX Export

@article{citeulike:5804382, abstract = {10.1101/gr.10.8.1172 Computational analysis of sequences of proteins involved in translation initiation in eukaryotes reveals a number of specific domains that are not represented in bacteria or archaea. Most of these eukaryote-specific domains are known or predicted to possess an \^{I}\$\\pm\$-helical structure, which suggests that such domains are easier to invent in the course of evolution than are domains of other structural classes. A previously undetected, conserved region predicted to form an \^{I}\$\\pm\$-helical domain is delineated in the initiation factor eIF4G, inonsense-mediated RNA ecay protein (NMD2/UPF2), in the nuclear cap-binding CBP80, and in other, poorly characterized proteins, which is named the NIC (MD2, eF4G, BP80) domain. Biochemical and mutagenesis data on NIC-containing proteins indicate that this predicted domain is one of the central adapters in the regulation of mRNA processing, translation, and degradation. It is demonstrated that, in the course of eukaryotic evolution, initiation factor eIF4G, of which NIC is the core, conserved portion, has accreted several additional, distinct predicted domains such as MI (A-3 and eF4G ) and W2, which probably was accompanied by acquisition of new regulatory interactions.}, author = {Aravind, L. and Koonin, Eugene V.}, citeulike-article-id = {5804382}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gr.10.8.1172}, citeulike-linkout-1 = {http://genome.cshlp.org/content/10/8/1172.abstract}, citeulike-linkout-2 = {http://genome.cshlp.org/content/10/8/1172.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/10958635}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=10958635}, day = {1}, doi = {10.1101/gr.10.8.1172}, journal = {Genome Research}, keywords = {aravind, enzyme, eukaryote, evolution, factor, inactive, regulation, translation}, month = {Aug}, number = {8}, pages = {1172--1184}, posted-at = {2009-09-18 23:20:10}, priority = {2}, title = {Eukaryote-specific Domains in Translation Initiation Factors: Implications for Translation Regulation and Evolution of the Translation System}, url = {http://dx.doi.org/10.1101/gr.10.8.1172}, volume = {10}, year = {2000} }

TY - JOUR ID - citeulike:5804382 L3 - citeulike-article-id:5804382 N2 - 10.1101/gr.10.8.1172 Computational analysis of sequences of proteins involved in translation initiation in eukaryotes reveals a number of specific domains that are not represented in bacteria or archaea. Most of these eukaryote-specific domains are known or predicted to possess an Î$\\pm$-helical structure, which suggests that such domains are easier to invent in the course of evolution than are domains of other structural classes. A previously undetected, conserved region predicted to form an Î$\\pm$-helical domain is delineated in the initiation factor eIF4G, inonsense-mediated RNA ecay protein (NMD2/UPF2), in the nuclear cap-binding CBP80, and in other, poorly characterized proteins, which is named the NIC (MD2, eF4G, BP80) domain. Biochemical and mutagenesis data on NIC-containing proteins indicate that this predicted domain is one of the central adapters in the regulation of mRNA processing, translation, and degradation. It is demonstrated that, in the course of eukaryotic evolution, initiation factor eIF4G, of which NIC is the core, conserved portion, has accreted several additional, distinct predicted domains such as MI (A-3 and eF4G ) and W2, which probably was accompanied by acquisition of new regulatory interactions. IS - 8 JF - Genome Research EP - 1184 TI - Eukaryote-specific Domains in Translation Initiation Factors: Implications for Translation Regulation and Evolution of the Translation System VL - 10 SP - 1172 KW - aravind KW - enzyme KW - eukaryote KW - evolution KW - factor KW - inactive KW - regulation KW - translation AU - Aravind, L AU - Koonin, Eugene PY - 2000/Aug/01/ UR - http://dx.doi.org/10.1101/gr.10.8.1172 ER -