B cells and tertiary lymphoid organs in renal inflammation. Export

@article{citeulike:2278732, abstract = {B lymphocytes are part of the inflammatory cells recruited to the human kidney in various disease settings. B cell infiltrates have been described in renal allografts, in acute and chronic interstitial nephritis, and the most common glomerular diseases like immunoglobulin A (IgA) and membranous nephropathy. These cells are almost exclusively recruited to the tubulointerstitium, but not the glomerular tuft. In addition to diffuse tubulointerstitial infiltrates, B cells together with T cells and dendritic cells form organized nodular aggregates surrounded by neo-lymphatic vessels. The functional significance of these tertiary lymphoid organs remains to be fully defined. Intrarenal B cells may be part of a local system to enhance the immunological response by functioning as antigen presenting cells, and as a source for cytokines promoting T-cell proliferation and lymphatic neoangiogenesis. In this way, they could enhance the local immune response to persisting autoantigens in the tubulointerstitium.Kidney International advance online publication, 19 December 2007; doi:10.1038/sj.ki.5002734.}, address = {1Medizinische Poliklinik, University of Munich, Munich, Germany.}, author = {Segerer, S and Schl\"{o}ndorff, D}, citeulike-article-id = {2278732}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.ki.5002734}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/5002734a}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18094677}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18094677}, day = {19}, doi = {10.1038/sj.ki.5002734}, issn = {0085-2538}, journal = {Kidney Int}, keywords = {b-cell}, month = {December}, posted-at = {2008-02-22 15:29:03}, priority = {2}, title = {B cells and tertiary lymphoid organs in renal inflammation.}, url = {http://dx.doi.org/10.1038/sj.ki.5002734}, year = {2007} }

TY - JOUR ID - citeulike:2278732 L3 - citeulike-article-id:2278732 N2 - B lymphocytes are part of the inflammatory cells recruited to the human kidney in various disease settings. B cell infiltrates have been described in renal allografts, in acute and chronic interstitial nephritis, and the most common glomerular diseases like immunoglobulin A (IgA) and membranous nephropathy. These cells are almost exclusively recruited to the tubulointerstitium, but not the glomerular tuft. In addition to diffuse tubulointerstitial infiltrates, B cells together with T cells and dendritic cells form organized nodular aggregates surrounded by neo-lymphatic vessels. The functional significance of these tertiary lymphoid organs remains to be fully defined. Intrarenal B cells may be part of a local system to enhance the immunological response by functioning as antigen presenting cells, and as a source for cytokines promoting T-cell proliferation and lymphatic neoangiogenesis. In this way, they could enhance the local immune response to persisting autoantigens in the tubulointerstitium.Kidney International advance online publication, 19 December 2007; doi:10.1038/sj.ki.5002734. JF - Kidney Int SN - 0085-2538 AD - 1Medizinische Poliklinik, University of Munich, Munich, Germany. TI - B cells and tertiary lymphoid organs in renal inflammation. KW - b-cell AU - Segerer, S AU - Schlöndorff, D PY - 2007/12/19/ UR - http://dx.doi.org/10.1038/sj.ki.5002734 ER -