Four Stages and Lack of Stable Accommodation in Chronic Alloantibody-Mediated Renal Allograft Rejection in Cynomolgus Monkeys Export

@article{citeulike:2894676, abstract = {The etiology of immunologically mediated chronic renal allograft failure is unclear. One cause is thought to be alloantibodies. Previously in Cynomolgus monkeys, we observed a relationship among donor-specific alloantibodies (DSA), C4d staining, allograft glomerulopathy, allograft arteriopathy and progressive renal failure. To define the natural history of chronic antibody-mediated rejection and its effect on renal allograft survival, we now extend this report to include 417 specimens from 143 Cynomolgus monkeys with renal allografts. A subset of animals with long-term renal allografts made DSA (48\%), were C4d positive (29\%), developed transplant glomerulopathy (TG) (22\%) and chronic allograft arteriopathy (CAA) (19\%). These four features were highly correlated and associated with statistically significant shortened allograft survival. Acute cellular rejection, either Banff type 1 or 2, did not correlate with alloantibodies, C4d deposition or TG. However, endarteritis (Banff type 2) correlated with later CAA. Sequential analysis identified four progressive stages of chronic antibody-mediated rejection: (1) DSA, (2) deposition of C4d, (3) TG and (4) rising creatinine/renal failure. These new findings provide strong evidence that chronic antibody-mediated rejection develops without enduring stable accommodation, progresses through four defined clinical pathological stages and shortens renal allograft survival.}, author = {Smith, R. N. and Kawai, T. and Boskovic, S. and Nadazdin, O. and Sachs, D. H. and Cosimi, A. B. and Colvin, R. B.}, citeulike-article-id = {2894676}, citeulike-linkout-0 = {http://www.blackwell-synergy.com/doi/abs/10.1111/j.1600-6143.2008.02303.x}, citeulike-linkout-1 = {http://dx.doi.org/10.1111/j.1600-6143.2008.02303.x}, doi = {10.1111/j.1600-6143.2008.02303.x}, journal = {American Journal of Transplantation}, keywords = {accommodation, humoral-rejection, transplant, transplant-glomerulopathy}, number = {0}, pages = {???}, posted-at = {2008-06-14 13:59:59}, priority = {3}, title = {Four Stages and Lack of Stable Accommodation in Chronic Alloantibody-Mediated Renal Allograft Rejection in Cynomolgus Monkeys}, url = {http://dx.doi.org/10.1111/j.1600-6143.2008.02303.x}, volume = {0}, year = {0} }

TY - JOUR ID - citeulike:2894676 L3 - citeulike-article-id:2894676 N2 - The etiology of immunologically mediated chronic renal allograft failure is unclear. One cause is thought to be alloantibodies. Previously in Cynomolgus monkeys, we observed a relationship among donor-specific alloantibodies (DSA), C4d staining, allograft glomerulopathy, allograft arteriopathy and progressive renal failure. To define the natural history of chronic antibody-mediated rejection and its effect on renal allograft survival, we now extend this report to include 417 specimens from 143 Cynomolgus monkeys with renal allografts. A subset of animals with long-term renal allografts made DSA (48%), were C4d positive (29%), developed transplant glomerulopathy (TG) (22%) and chronic allograft arteriopathy (CAA) (19%). These four features were highly correlated and associated with statistically significant shortened allograft survival. Acute cellular rejection, either Banff type 1 or 2, did not correlate with alloantibodies, C4d deposition or TG. However, endarteritis (Banff type 2) correlated with later CAA. Sequential analysis identified four progressive stages of chronic antibody-mediated rejection: (1) DSA, (2) deposition of C4d, (3) TG and (4) rising creatinine/renal failure. These new findings provide strong evidence that chronic antibody-mediated rejection develops without enduring stable accommodation, progresses through four defined clinical pathological stages and shortens renal allograft survival. IS - 0 JF - American Journal of Transplantation EP - ??? TI - Four Stages and Lack of Stable Accommodation in Chronic Alloantibody-Mediated Renal Allograft Rejection in Cynomolgus Monkeys VL - 0 SP - ??? KW - accommodation KW - humoral-rejection KW - transplant KW - transplant-glomerulopathy AU - Smith, RN AU - Kawai, T AU - Boskovic, S AU - Nadazdin, O AU - Sachs, DH AU - Cosimi, AB AU - Colvin, RB PY - 2000/// UR - http://dx.doi.org/10.1111/j.1600-6143.2008.02303.x ER -