Anti-CD20 Monoclonal Antibody (Rituximab) for the Treatment of Membranous Nephropathy After Living-Unrelated Kidney Transplantation: A Case Report. Export

@article{citeulike:3334539, abstract = {A 41-year-old Thai male with end-stage renal disease of uncertain etiology started chronic hemodialysis in November 2001. Two years later, he underwent a living unrelated, four HLA mismatched, kidney transplantation from his wife. Pretransplant class I panel reactive antibody was 80\% and the cross-match was positive for immunoglobulin (Ig)M. There was no complication until 30 months after transplantation, when he developed frank nephrotic syndrome with 12.9 g/day of proteinuria. Serum creatinine was 1.5 mg/dL. Allograft biopsy showed membranous nephropathy and mild acute cellular rejection with plasma cell infiltration. In addition to enalapril, valsartan, and simvastatin, a single dose of rituximab (375 mg/m(2)) and a 3-day course of pulse methylprednisolone were prescribe for the acute rejection episode. The patient was maintained on the same immunosuppressive regimen: cyclosporine, azathioprine, and prednisolone. Five months after the therapy, proteinuria was reduced to 0.5 g/day with a normalized serum albumin level. At 4 years post transplantation, his renal function remains stable. His serum albumin is 4.5 g/dL and urine protein-to-creatinine ratio 0.2.}, address = {Division of Nephrology, Department of Medicine, Siriraj Hospital, Bangkok, Thailand.}, author = {Sirimongkolrat, T. and Premasathian, N. and Vongwiwatana, A. and Limsrichamrern, S. and Cheunsuchon, B. and Vasuvattakul, S.}, citeulike-article-id = {3334539}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.transproceed.2008.07.074}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18790261}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18790261}, doi = {10.1016/j.transproceed.2008.07.074}, issn = {0041-1345}, journal = {Transplantation proceedings}, keywords = {membranous-nephropathy, recurrent-glomerulonephritis, transplant, transplant-proteinuria}, month = {September}, number = {7}, pages = {2440--2441}, posted-at = {2008-09-25 03:24:28}, priority = {2}, title = {Anti-CD20 Monoclonal Antibody (Rituximab) for the Treatment of Membranous Nephropathy After Living-Unrelated Kidney Transplantation: A Case Report.}, url = {http://dx.doi.org/10.1016/j.transproceed.2008.07.074}, volume = {40}, year = {2008} }

TY - JOUR ID - citeulike:3334539 L3 - citeulike-article-id:3334539 N2 - A 41-year-old Thai male with end-stage renal disease of uncertain etiology started chronic hemodialysis in November 2001. Two years later, he underwent a living unrelated, four HLA mismatched, kidney transplantation from his wife. Pretransplant class I panel reactive antibody was 80% and the cross-match was positive for immunoglobulin (Ig)M. There was no complication until 30 months after transplantation, when he developed frank nephrotic syndrome with 12.9 g/day of proteinuria. Serum creatinine was 1.5 mg/dL. Allograft biopsy showed membranous nephropathy and mild acute cellular rejection with plasma cell infiltration. In addition to enalapril, valsartan, and simvastatin, a single dose of rituximab (375 mg/m(2)) and a 3-day course of pulse methylprednisolone were prescribe for the acute rejection episode. The patient was maintained on the same immunosuppressive regimen: cyclosporine, azathioprine, and prednisolone. Five months after the therapy, proteinuria was reduced to 0.5 g/day with a normalized serum albumin level. At 4 years post transplantation, his renal function remains stable. His serum albumin is 4.5 g/dL and urine protein-to-creatinine ratio 0.2. IS - 7 JF - Transplantation proceedings SN - 0041-1345 AD - Division of Nephrology, Department of Medicine, Siriraj Hospital, Bangkok, Thailand. EP - 2441 TI - Anti-CD20 Monoclonal Antibody (Rituximab) for the Treatment of Membranous Nephropathy After Living-Unrelated Kidney Transplantation: A Case Report. VL - 40 SP - 2440 KW - membranous-nephropathy KW - recurrent-glomerulonephritis KW - transplant KW - transplant-proteinuria AU - Sirimongkolrat, T AU - Premasathian, N AU - Vongwiwatana, A AU - Limsrichamrern, S AU - Cheunsuchon, B AU - Vasuvattakul, S PY - 2008/09// UR - http://dx.doi.org/10.1016/j.transproceed.2008.07.074 ER -