Organically Modified Silica Nanoparticles with Covalently Incorporated Photosensitizer for Photodynamic Therapy of Cancer Export

@article{citeulike:1790898, abstract = {Abstract: We report a novel nanoformulation of a photosensitizer (PS), for photodynamic therapy (PDT) of cancer, where the PS molecules are covalently incorporated into organically modified silica (ORMOSIL) nanoparticles. We found that the covalently incorporated PS molecules retained their spectroscopic and functional properties and could robustly generate cytotoxic singlet oxygen molecules upon photoirradiation. The synthesized nanoparticles are of ultralow size (\~{}20 nm) and are highly monodispersed and stable in aqueous suspension. The advantage offered by this covalently linked nanofabrication is that the drug is not released during systemic circulation, which is often a problem with physical encapsulation. These nanoparticles are also avidly uptaken by tumor cells in vitro and demonstrate phototoxic action, thereby highlighting their potential in diagnosis and PDT of cancer.}, address = {Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York, and PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York}, author = {Ohulchanskyy, T. Y. and Roy, I. and Goswami, L. N. and Chen, Y. and Bergey, E. J. and Pandey, R. K. and Oseroff, A. R. and Prasad, P. N.}, citeulike-article-id = {1790898}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/nl0714637}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/nl0714637}, citeulike-linkout-2 = {http://www.scopus.com/record/display.url?view=extended&origin=resultslist&eid=2-s2.0-34948909249}, day = {12}, doi = {10.1021/nl0714637}, journal = {Nano Lett.}, keywords = {cancer, citedby4, nanoparticles, ormosil, pdt, photodynamic, photosensitizers, silica, therapy}, month = {September}, number = {9}, pages = {2835--2842}, posted-at = {2007-10-20 01:05:53}, priority = {2}, title = {Organically Modified Silica Nanoparticles with Covalently Incorporated Photosensitizer for Photodynamic Therapy of Cancer}, url = {http://dx.doi.org/10.1021/nl0714637}, volume = {7}, year = {2007} }

TY - JOUR ID - citeulike:1790898 L3 - citeulike-article-id:1790898 N2 - Abstract: We report a novel nanoformulation of a photosensitizer (PS), for photodynamic therapy (PDT) of cancer, where the PS molecules are covalently incorporated into organically modified silica (ORMOSIL) nanoparticles. We found that the covalently incorporated PS molecules retained their spectroscopic and functional properties and could robustly generate cytotoxic singlet oxygen molecules upon photoirradiation. The synthesized nanoparticles are of ultralow size (~20 nm) and are highly monodispersed and stable in aqueous suspension. The advantage offered by this covalently linked nanofabrication is that the drug is not released during systemic circulation, which is often a problem with physical encapsulation. These nanoparticles are also avidly uptaken by tumor cells in vitro and demonstrate phototoxic action, thereby highlighting their potential in diagnosis and PDT of cancer. IS - 9 JF - Nano Lett. AD - Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York, and PDT Center, Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York EP - 2842 TI - Organically Modified Silica Nanoparticles with Covalently Incorporated Photosensitizer for Photodynamic Therapy of Cancer VL - 7 SP - 2835 KW - cancer KW - citedby4 KW - nanoparticles KW - ormosil KW - pdt KW - photodynamic KW - photosensitizers KW - silica KW - therapy AU - Ohulchanskyy, TY AU - Roy, I AU - Goswami, LN AU - Chen, Y AU - Bergey, EJ AU - Pandey, RK AU - Oseroff, AR AU - Prasad, PN PY - 2007/09/12/ UR - http://dx.doi.org/10.1021/nl0714637 ER -