Collective alignment of polar filaments by molecular motors Export

@article{citeulike:4264925, abstract = {Abstract\ \ We study the alignment of polar biofilaments, such as microtubules and actin, subject to the action of multiple molecular motors attached simultaneously to more than one filament. Focusing on a paradigm model of only two filaments interacting with multiple motors, we were able to investigate in detail the alignment dynamics. While almost no alignment occurs in the case of a single motor, the filaments become rapidly aligned due to the collective action of the motors. Our analysis shows that the alignment time is governed by the number of bound motors and the magnitude of the motors' stepping fluctuations. We predict that the time scale of alignment is in the order of seconds, much faster than that reported for passive crosslink-induced bundling. In vitro experiments on the alignment of microtubules by multiple-motor covered beads are in qualitative agreement. We also discuss another mode of fast alignment of filaments, namely the cooperation between motors and passive crosslinks.}, author = {Ziebert, F. and Vershinin, M. and Gross, S. and Aranson, I.}, citeulike-article-id = {4264925}, citeulike-linkout-0 = {http://dx.doi.org/10.1140/epje/i2008-10434-0}, citeulike-linkout-1 = {http://www.springerlink.com/content/u1462g8t3t051k0h}, citeulike-linkout-2 = {http://dx.doi.org/10.1140/epje/i2008-10434-0}, day = {1}, doi = {10.1140/epje/i2008-10434-0}, journal = {The European Physical Journal E: Soft Matter and Biological Physics}, keywords = {alignment, coupling, filaments, journalclub, microtubules, motor, proteins}, month = {April}, number = {4}, pages = {401--409}, posted-at = {2009-11-09 01:39:37}, priority = {4}, title = {Collective alignment of polar filaments by molecular motors}, url = {http://dx.doi.org/10.1140/epje/i2008-10434-0}, volume = {28}, year = {2009} }

TY - JOUR ID - citeulike:4264925 L3 - citeulike-article-id:4264925 N2 - Abstract  We study the alignment of polar biofilaments, such as microtubules and actin, subject to the action of multiple molecular motors attached simultaneously to more than one filament. Focusing on a paradigm model of only two filaments interacting with multiple motors, we were able to investigate in detail the alignment dynamics. While almost no alignment occurs in the case of a single motor, the filaments become rapidly aligned due to the collective action of the motors. Our analysis shows that the alignment time is governed by the number of bound motors and the magnitude of the motors’ stepping fluctuations. We predict that the time scale of alignment is in the order of seconds, much faster than that reported for passive crosslink-induced bundling. In vitro experiments on the alignment of microtubules by multiple-motor covered beads are in qualitative agreement. We also discuss another mode of fast alignment of filaments, namely the cooperation between motors and passive crosslinks. IS - 4 JF - The European Physical Journal E: Soft Matter and Biological Physics EP - 409 TI - Collective alignment of polar filaments by molecular motors VL - 28 SP - 401 KW - alignment KW - coupling KW - filaments KW - journalclub KW - microtubules KW - motor KW - proteins AU - Ziebert, F AU - Vershinin, M AU - Gross, S AU - Aranson, I PY - 2009/04/01/ UR - http://dx.doi.org/10.1140/epje/i2008-10434-0 ER -