Muscular Thin Films for Building Actuators and Powering Devices Export

@article{citeulike:5394262, abstract = {We demonstrate the assembly of biohybrid materials from engineered tissues and synthetic polymer thin films. The constructs were built by culturing neonatal rat ventricular cardiomyocytes on polydimethylsiloxane thin films micropatterned with extracellular matrix proteins to promote spatially ordered, two-dimensional myogenesis. The constructs, termed muscular thin films, adopted functional, three-dimensional conformations when released from a thermally sensitive polymer substrate and were designed to perform biomimetic tasks by varying tissue architecture, thin-film shape, and electrical-pacing protocol. These centimeter-scale constructs perform functions as diverse as gripping, pumping, walking, and swimming with fine spatial and temporal control and generating specific forces as high as 4 millinewtons per square millimeter. 10.1126/science.1146885}, author = {Feinberg, Adam W. and Feigel, Alex and Shevkoplyas, Sergey S. and Sheehy, Sean and Whitesides, George M. and Parker, Kevin K.}, citeulike-article-id = {5394262}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1146885}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/317/5843/1366}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17823347}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17823347}, day = {7}, doi = {10.1126/science.1146885}, journal = {Science}, keywords = {actuators, films, muscle, tissue, top-down}, month = {September}, number = {5843}, pages = {1366--1370}, posted-at = {2009-08-07 19:06:40}, priority = {5}, title = {Muscular Thin Films for Building Actuators and Powering Devices}, url = {http://dx.doi.org/10.1126/science.1146885}, volume = {317}, year = {2007} }

TY - JOUR ID - citeulike:5394262 L3 - citeulike-article-id:5394262 N2 - We demonstrate the assembly of biohybrid materials from engineered tissues and synthetic polymer thin films. The constructs were built by culturing neonatal rat ventricular cardiomyocytes on polydimethylsiloxane thin films micropatterned with extracellular matrix proteins to promote spatially ordered, two-dimensional myogenesis. The constructs, termed muscular thin films, adopted functional, three-dimensional conformations when released from a thermally sensitive polymer substrate and were designed to perform biomimetic tasks by varying tissue architecture, thin-film shape, and electrical-pacing protocol. These centimeter-scale constructs perform functions as diverse as gripping, pumping, walking, and swimming with fine spatial and temporal control and generating specific forces as high as 4 millinewtons per square millimeter. 10.1126/science.1146885 IS - 5843 JF - Science EP - 1370 TI - Muscular Thin Films for Building Actuators and Powering Devices VL - 317 SP - 1366 KW - actuators KW - films KW - muscle KW - tissue KW - top-down AU - Feinberg, Adam AU - Feigel, Alex AU - Shevkoplyas, Sergey AU - Sheehy, Sean AU - Whitesides, George AU - Parker, Kevin PY - 2007/09/07/ UR - http://dx.doi.org/10.1126/science.1146885 ER -