Antiphospholipid antibodies: Paradigm in transition Export

@article{citeulike:3914590, abstract = {OBJECTIVES:This is a critical review of anti-phospholipid antibodies (aPL). Most prior reviews focus on the aPL syndrome (APS), a thrombotic condition often marked by neurological disturbance. We bring to attention recent evidence that aPL may be equally relevant to non-thrombotic autoimmune conditions, notably, multiple sclerosis and ITP.ORGANIZATION:After a brief history, the recent proliferation of aPL target antigens is reviewed. The implication is that many more exist. Theories of aPL in thrombosis are then reviewed, concluding that all have merit but that aPL may have more diverse pathological consequences than now recognized. Next, conflicting results are explained by methodological differences. The lupus anticoagulant (LA) is then discussed. LA is the best predictor of thrombosis, but why this is true is not settled. Finally, aPL in non-thrombotic disorders is reviewed.CONCLUSION:The current paradigm of aPL holds that they are important in thrombosis, but they may have much wider clinical significance, possibly of special interest in neurology.}, author = {Horstman, Lawrence and Jy, Wenche and Bidot, Carlos and Ahn, Yeon and Kelley, Roger and Zivadinov, Robert and Maghzi, Amir and Etemadifar, Masoud and Mousavi, Seyed and Minagar, Alireza}, citeulike-article-id = {3914590}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1742-2094-6-3}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19154576}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19154576}, day = {20}, doi = {10.1186/1742-2094-6-3}, issn = {1742-2094}, journal = {Journal of Neuroinflammation}, keywords = {phospholipid, rhdl}, month = {January}, number = {1}, pages = {3+}, posted-at = {2009-07-22 06:18:44}, priority = {2}, title = {Antiphospholipid antibodies: Paradigm in transition}, url = {http://dx.doi.org/10.1186/1742-2094-6-3}, volume = {6}, year = {2009} }

TY - JOUR ID - citeulike:3914590 L3 - citeulike-article-id:3914590 N2 - OBJECTIVES:This is a critical review of anti-phospholipid antibodies (aPL). Most prior reviews focus on the aPL syndrome (APS), a thrombotic condition often marked by neurological disturbance. We bring to attention recent evidence that aPL may be equally relevant to non-thrombotic autoimmune conditions, notably, multiple sclerosis and ITP.ORGANIZATION:After a brief history, the recent proliferation of aPL target antigens is reviewed. The implication is that many more exist. Theories of aPL in thrombosis are then reviewed, concluding that all have merit but that aPL may have more diverse pathological consequences than now recognized. Next, conflicting results are explained by methodological differences. The lupus anticoagulant (LA) is then discussed. LA is the best predictor of thrombosis, but why this is true is not settled. Finally, aPL in non-thrombotic disorders is reviewed.CONCLUSION:The current paradigm of aPL holds that they are important in thrombosis, but they may have much wider clinical significance, possibly of special interest in neurology. IS - 1 JF - Journal of Neuroinflammation SN - 1742-2094 TI - Antiphospholipid antibodies: Paradigm in transition VL - 6 SP - 3 KW - phospholipid KW - rhdl AU - Horstman, Lawrence AU - Jy, Wenche AU - Bidot, Carlos AU - Ahn, Yeon AU - Kelley, Roger AU - Zivadinov, Robert AU - Maghzi, Amir AU - Etemadifar, Masoud AU - Mousavi, Seyed AU - Minagar, Alireza PY - 2009/01/20/ UR - http://dx.doi.org/10.1186/1742-2094-6-3 ER -