Evolution of Eukaryotic Transcription Circuits Export

@article{citeulike:2608012, abstract = {The gradual modification of transcription circuits over evolutionary time scales is an important source of the diversity of life. Over the past decade, studies in animals have shown how seemingly small molecular changes in gene regulation can have large effects on morphology and physiology and how selective pressures can act on these changes. More recently, genome-wide studies, particularly those in single-cell yeasts, have uncovered evidence of extensive transcriptional rewiring, indicating that even closely related organisms regulate their genes using markedly different circuitries. 10.1126/science.1152398}, author = {Tuch, Brian B. and Li, Hao and Johnson, Alexander D.}, citeulike-article-id = {2608012}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1152398}, citeulike-linkout-1 = {http://www.sciencemag.org/content/319/5871/1797.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/319/5871/1797.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/319/5871/1797}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/18369141}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=18369141}, day = {28}, doi = {10.1126/science.1152398}, journal = {Science}, keywords = {evolution, rewiring, tfnets}, month = {March}, number = {5871}, pages = {1797--1799}, posted-at = {2009-10-15 00:22:56}, priority = {2}, title = {Evolution of Eukaryotic Transcription Circuits}, url = {http://dx.doi.org/10.1126/science.1152398}, volume = {319}, year = {2008} }

TY - JOUR ID - citeulike:2608012 L3 - citeulike-article-id:2608012 N2 - The gradual modification of transcription circuits over evolutionary time scales is an important source of the diversity of life. Over the past decade, studies in animals have shown how seemingly small molecular changes in gene regulation can have large effects on morphology and physiology and how selective pressures can act on these changes. More recently, genome-wide studies, particularly those in single-cell yeasts, have uncovered evidence of extensive transcriptional rewiring, indicating that even closely related organisms regulate their genes using markedly different circuitries. 10.1126/science.1152398 IS - 5871 JF - Science EP - 1799 TI - Evolution of Eukaryotic Transcription Circuits VL - 319 SP - 1797 KW - evolution KW - rewiring KW - tfnets AU - Tuch, Brian AU - Li, Hao AU - Johnson, Alexander PY - 2008/03/28/ UR - http://dx.doi.org/10.1126/science.1152398 ER -