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Fast and Accurate Read Alignment for Resequencing

by: John C. Mu, Hui Jiang, Amirhossein Kiani, Marghoob Mohiyuddin, Narges B. Asadi, Wing H. Wong
Bioinformatics, Vol. 28, No. 18. (18 July 2012), pp. 2366-2373, doi:10.1093/bioinformatics/bts450  Key: citeulike:10902449

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Abstract

Motivation: Next generation sequence analysis has become an important task both in laboratory and clinical settings. A key stage in the majority sequence analysis workflows, such as resequencing, is the alignment of genomic reads to a reference genome. The accurate alignment of reads with large indels is a computationally challenging task for researchers.


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