Epigenetic nucleosomes: Alu sequences and CG as nucleosome positioning element. Export

@article{citeulike:3140519, abstract = {Alu sequences carry periodical pattern with CG dinucleotides (CpG) repeating every 31-32 bases. Similar distances are observed in distribution of DNA curvature in crystallized nucleosomes, at positions +/-1.5 and +/-4.5 periods of DNA from nucleosome DNA dyad. Since CG elements are also found to impart to nucleosomes higher stability when positioned at +/-1.5 sites, it suggests that CG dinucleotides may play a role in modulation of the nucleosome strength when the CG elements are methylated. Thus, Alu sequences may harbor special epigenetic nucleosomes with methylation-dependent regulatory functions. Nucleosome DNA sequence probe is suggested to detect locations of such regulatory nucleosomes in the sequences.}, address = {Genome Diversity Center, Institute of Evolution, University of Haifa, Israel.}, author = {Salih, F. and Salih, B. and Kogan, S. and Trifonov, E. N.}, citeulike-article-id = {3140519}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18533722}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18533722}, issn = {0739-1102}, journal = {Journal of biomolecular structure \& dynamics}, keywords = {alu, cpg, dna-methylation, nucleosome, periodicity}, month = {August}, number = {1}, pages = {9--16}, posted-at = {2008-08-20 15:09:42}, priority = {2}, title = {Epigenetic nucleosomes: Alu sequences and CG as nucleosome positioning element.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18533722}, volume = {26}, year = {2008} }

TY - JOUR ID - citeulike:3140519 L3 - citeulike-article-id:3140519 N2 - Alu sequences carry periodical pattern with CG dinucleotides (CpG) repeating every 31-32 bases. Similar distances are observed in distribution of DNA curvature in crystallized nucleosomes, at positions +/-1.5 and +/-4.5 periods of DNA from nucleosome DNA dyad. Since CG elements are also found to impart to nucleosomes higher stability when positioned at +/-1.5 sites, it suggests that CG dinucleotides may play a role in modulation of the nucleosome strength when the CG elements are methylated. Thus, Alu sequences may harbor special epigenetic nucleosomes with methylation-dependent regulatory functions. Nucleosome DNA sequence probe is suggested to detect locations of such regulatory nucleosomes in the sequences. IS - 1 JF - Journal of biomolecular structure & dynamics SN - 0739-1102 AD - Genome Diversity Center, Institute of Evolution, University of Haifa, Israel. EP - 16 TI - Epigenetic nucleosomes: Alu sequences and CG as nucleosome positioning element. VL - 26 SP - 9 KW - alu KW - cpg KW - dna-methylation KW - nucleosome KW - periodicity AU - Salih, F AU - Salih, B AU - Kogan, S AU - Trifonov, EN PY - 2008/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/18533722 ER -