Epigenetic mechanisms in mammals. Export

@article{citeulike:3936884, abstract = {DNA and histone methylation are linked and subjected to mitotic inheritance in mammals. Yet how methylation is propagated and maintained between successive cell divisions is not fully understood. A series of enzyme families that can add methylation marks to cytosine nucleobases, and lysine and arginine amino acid residues has been discovered. Apart from methyltransferases, there are also histone modification enzymes and accessory proteins, which can facilitate and/or target epigenetic marks. Several lysine and arginine demethylases have been discovered recently, and the presence of an active DNA demethylase is speculated in mammalian cells. A mammalian methyl DNA binding protein MBD2 and de novo DNA methyltransferase DNMT3A and DNMT3B are shown experimentally to possess DNA demethylase activity. Thus, complex mammalian epigenetic mechanisms appear to be dynamic yet reversible along with a well-choreographed set of events that take place during mammalian development.}, author = {Kim, J. K. and Samaranayake, M. and Pradhan, S.}, citeulike-article-id = {3936884}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00018-008-8432-4}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18985277}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18985277}, day = {3}, doi = {10.1007/s00018-008-8432-4}, issn = {1420-9071}, journal = {Cellular and molecular life sciences : CMLS}, keywords = {dna-methylation, dnmt3a, dnmt3b, epigenetics, histone-code, mbd2, review}, month = {February}, number = {4}, pages = {596--612}, posted-at = {2009-03-25 08:50:41}, priority = {2}, title = {Epigenetic mechanisms in mammals.}, url = {http://dx.doi.org/10.1007/s00018-008-8432-4}, volume = {66}, year = {2009} }

TY - JOUR ID - citeulike:3936884 L3 - citeulike-article-id:3936884 N2 - DNA and histone methylation are linked and subjected to mitotic inheritance in mammals. Yet how methylation is propagated and maintained between successive cell divisions is not fully understood. A series of enzyme families that can add methylation marks to cytosine nucleobases, and lysine and arginine amino acid residues has been discovered. Apart from methyltransferases, there are also histone modification enzymes and accessory proteins, which can facilitate and/or target epigenetic marks. Several lysine and arginine demethylases have been discovered recently, and the presence of an active DNA demethylase is speculated in mammalian cells. A mammalian methyl DNA binding protein MBD2 and de novo DNA methyltransferase DNMT3A and DNMT3B are shown experimentally to possess DNA demethylase activity. Thus, complex mammalian epigenetic mechanisms appear to be dynamic yet reversible along with a well-choreographed set of events that take place during mammalian development. IS - 4 JF - Cellular and molecular life sciences : CMLS SN - 1420-9071 EP - 612 TI - Epigenetic mechanisms in mammals. VL - 66 SP - 596 KW - dna-methylation KW - dnmt3a KW - dnmt3b KW - epigenetics KW - histone-code KW - mbd2 KW - review AU - Kim, JK AU - Samaranayake, M AU - Pradhan, S PY - 2009/02/03/ UR - http://dx.doi.org/10.1007/s00018-008-8432-4 ER -