Antisense transcription occurs at the promoter of a mouse imprinted gene, Commd1, on the repressed paternal allele. Export

@article{citeulike:5811714, abstract = {The Commd1 gene is imprinted in the adult mouse brain and is predominantly expressed from the maternal allele. A paternally expressing imprinted gene, U2af1-rs1, resides in the first intron of Commd1 in an antisense orientation. We found that RNA polymerase II phosphorylated at serine 2 of the carboxyl-terminal domain repeats, a marker of transcription elongation, is enriched on the paternal allele than on the maternal allele of the Commd1 promoter. The Commd1 promoter harbors no allelic differences in DNA methylation and histone modifications. These results strongly suggested that imprinting of Commd1 is generated by interference with paternal Commd1 transcription by the oppositely directed U2af1-rs1 transcription.}, author = {Joh, Keiichiro and Yatsuki, Hitomi and Higashimoto, Ken and Mukai, Tsunehiro and Soejima, Hidenobu}, citeulike-article-id = {5811714}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/jb/mvp147}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19762339}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19762339}, day = {17}, doi = {10.1093/jb/mvp147}, issn = {1756-2651}, journal = {Journal of biochemistry}, keywords = {antisense, commd1, imprinting, interference, transcription, u2af1-rs1}, month = {September}, posted-at = {2009-09-21 10:32:02}, priority = {2}, title = {Antisense transcription occurs at the promoter of a mouse imprinted gene, Commd1, on the repressed paternal allele.}, url = {http://dx.doi.org/10.1093/jb/mvp147}, year = {2009} }

TY - JOUR ID - citeulike:5811714 L3 - citeulike-article-id:5811714 N2 - The Commd1 gene is imprinted in the adult mouse brain and is predominantly expressed from the maternal allele. A paternally expressing imprinted gene, U2af1-rs1, resides in the first intron of Commd1 in an antisense orientation. We found that RNA polymerase II phosphorylated at serine 2 of the carboxyl-terminal domain repeats, a marker of transcription elongation, is enriched on the paternal allele than on the maternal allele of the Commd1 promoter. The Commd1 promoter harbors no allelic differences in DNA methylation and histone modifications. These results strongly suggested that imprinting of Commd1 is generated by interference with paternal Commd1 transcription by the oppositely directed U2af1-rs1 transcription. JF - Journal of biochemistry SN - 1756-2651 TI - Antisense transcription occurs at the promoter of a mouse imprinted gene, Commd1, on the repressed paternal allele. KW - antisense KW - commd1 KW - imprinting KW - interference KW - transcription KW - u2af1-rs1 AU - Joh, Keiichiro AU - Yatsuki, Hitomi AU - Higashimoto, Ken AU - Mukai, Tsunehiro AU - Soejima, Hidenobu PY - 2009/09/17/ UR - http://dx.doi.org/10.1093/jb/mvp147 ER -