Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis. Export

@article{citeulike:5844019, abstract = {Balanced maternal and paternal genome contributions are a requirement for successful seed development. Unbalanced contributions often cause seed abortion, a phenomenon that has been termed "triploid block." Misregulation of imprinted regulatory genes has been proposed to be the underlying cause for abnormalities in growth and structure of the endosperm in seeds with deviating parental contributions. We identified a mutant forming unreduced pollen that enabled us to investigate direct effects of unbalanced parental genome contributions on seed development and to reveal the underlying molecular mechanism of dosage sensitivity. We provide evidence that parent-of-origin-specific expression of the Polycomb group (PcG) gene MEDEA is causally responsible for seed developmental aberrations in Arabidopsis seeds with increased paternal genome contributions. We propose that imprinted expression of PcG genes is an evolutionary conserved mechanism to balance parental genome contributions in embryo nourishing tissues.}, author = {Erilova, Aleksandra and Brownfield, Lynette and Exner, Vivien and Rosa, Marisa and Twell, David and Mittelsten Scheid, Ortrun and Hennig, Lars and K\"{o}hler, Claudia}, citeulike-article-id = {5844019}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.1000663}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19779546}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19779546}, day = {25}, doi = {10.1371/journal.pgen.1000663}, issn = {1553-7404}, journal = {PLoS genetics}, keywords = {arabidopsis, imprinting, medea, polyploidy}, month = {September}, number = {9}, pages = {e1000663+}, posted-at = {2009-10-05 09:09:11}, priority = {2}, publisher = {Public Library of Science}, title = {Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis.}, url = {http://dx.doi.org/10.1371/journal.pgen.1000663}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:5844019 L3 - citeulike-article-id:5844019 N2 - Balanced maternal and paternal genome contributions are a requirement for successful seed development. Unbalanced contributions often cause seed abortion, a phenomenon that has been termed "triploid block." Misregulation of imprinted regulatory genes has been proposed to be the underlying cause for abnormalities in growth and structure of the endosperm in seeds with deviating parental contributions. We identified a mutant forming unreduced pollen that enabled us to investigate direct effects of unbalanced parental genome contributions on seed development and to reveal the underlying molecular mechanism of dosage sensitivity. We provide evidence that parent-of-origin-specific expression of the Polycomb group (PcG) gene MEDEA is causally responsible for seed developmental aberrations in Arabidopsis seeds with increased paternal genome contributions. We propose that imprinted expression of PcG genes is an evolutionary conserved mechanism to balance parental genome contributions in embryo nourishing tissues. IS - 9 JF - PLoS genetics SN - 1553-7404 TI - Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis. PB - Public Library of Science VL - 5 SP - e1000663 KW - arabidopsis KW - imprinting KW - medea KW - polyploidy AU - Erilova, Aleksandra AU - Brownfield, Lynette AU - Exner, Vivien AU - Rosa, Marisa AU - Twell, David AU - Mittelsten Scheid, Ortrun AU - Hennig, Lars AU - Köhler, Claudia PY - 2009/09/25/ UR - http://dx.doi.org/10.1371/journal.pgen.1000663 ER -