Regulation of longevity and stress resistance by Sch9 in yeast. Export

@article{citeulike:3290189, abstract = {The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this life-span extension. These results indicate that longevity is associated with increased investment in maintenance and show that highly conserved genes play similar roles in life-span regulation in S. cerevisiae and higher eukaryotes.}, address = {Division of Biogerontology, Andrus Gerontology Center, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA.}, author = {Fabrizio, P. and Pozza, F. and Pletcher, S. D. and Gendron, C. M. and Longo, V. D.}, citeulike-article-id = {3290189}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1059497}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11292860}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11292860}, day = {13}, doi = {10.1126/science.1059497}, issn = {0036-8075}, journal = {Science (New York, N.Y.)}, keywords = {aging, pkb, proteinkinaseakt, sod, yeast, yvonne}, month = {April}, number = {5515}, pages = {288--290}, posted-at = {2008-09-18 20:12:06}, priority = {2}, title = {Regulation of longevity and stress resistance by Sch9 in yeast.}, url = {http://dx.doi.org/10.1126/science.1059497}, volume = {292}, year = {2001} }

TY - JOUR ID - citeulike:3290189 L3 - citeulike-article-id:3290189 N2 - The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this life-span extension. These results indicate that longevity is associated with increased investment in maintenance and show that highly conserved genes play similar roles in life-span regulation in S. cerevisiae and higher eukaryotes. IS - 5515 JF - Science (New York, N.Y.) SN - 0036-8075 AD - Division of Biogerontology, Andrus Gerontology Center, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA. EP - 290 TI - Regulation of longevity and stress resistance by Sch9 in yeast. VL - 292 SP - 288 KW - aging KW - pkb KW - proteinkinaseakt KW - sod KW - yeast KW - yvonne AU - Fabrizio, P AU - Pozza, F AU - Pletcher, SD AU - Gendron, CM AU - Longo, VD PY - 2001/04/13/ UR - http://dx.doi.org/10.1126/science.1059497 ER -