Evolutionary medicine: from dwarf model systems to healthy centenarians? Export

@article{citeulike:573395, abstract = {Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I-like signaling pathways extend life-span but also cause glycogen or fat accumulation and dwarfism. This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects.}, address = {Andrus Gerontology Center, Division of Biogerontology, and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA. vlongo@usc.edu}, author = {Longo, V. D. and Finch, C. E.}, citeulike-article-id = {573395}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1077991}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/299/5611/1342}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12610293}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12610293}, citeulike-linkout-4 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00013232}, day = {28}, doi = {10.1126/science.1077991}, issn = {1095-9203}, journal = {Science}, keywords = {aging, caloricrestriction, igf-1, inflammation, mice, review, yeast, yvonne}, month = {February}, number = {5611}, pages = {1342--1346}, posted-at = {2008-09-18 20:41:18}, priority = {2}, title = {Evolutionary medicine: from dwarf model systems to healthy centenarians?}, url = {http://dx.doi.org/10.1126/science.1077991}, volume = {299}, year = {2003} }

TY - JOUR ID - citeulike:573395 L3 - citeulike-article-id:573395 N2 - Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I-like signaling pathways extend life-span but also cause glycogen or fat accumulation and dwarfism. This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects. IS - 5611 JF - Science SN - 1095-9203 AD - Andrus Gerontology Center, Division of Biogerontology, and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA. vlongo@usc.edu EP - 1346 TI - Evolutionary medicine: from dwarf model systems to healthy centenarians? VL - 299 SP - 1342 KW - aging KW - caloricrestriction KW - igf-1 KW - inflammation KW - mice KW - review KW - yeast KW - yvonne AU - Longo, VD AU - Finch, CE PY - 2003/02/28/ UR - http://dx.doi.org/10.1126/science.1077991 ER -