Free-Energy Landscape of Enzyme Catalysis† Export

@article{benkovic2008, abstract = {PMID: 18298083 The concept is developed that enzyme mechanisms should be viewed as ” catalytic networks” with multiple conformations that occur serially and in parallel in the mechanism. These coupled ensembles of conformations require a multi-dimensional standard free-energy surface that is very ” rugged”, containing multiple minima and transition states. Experimental and theoretical evidence is presented to support this concept.}, address = {Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, and Department of Biochemistry, Box 3711, Duke University, Durham, North Carolina 27710}, author = {Benkovic, Stephen J. and Hammes, Gordon G. and Hammes-Schiffer, Sharon}, citeulike-article-id = {2637085}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/bi800049z}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/bi800049z}, day = {1}, doi = {10.1021/bi800049z}, journal = {Biochemistry}, keywords = {catalysis, dhfr, energy\_landscape, enzyme, free-energy}, month = {March}, number = {11}, pages = {3317--3321}, posted-at = {2008-04-07 11:36:53}, priority = {2}, title = {Free-Energy Landscape of Enzyme Catalysis{\dag}}, url = {http://dx.doi.org/10.1021/bi800049z}, volume = {47}, year = {2008} }

TY - JOUR ID - benkovic2008 L3 - citeulike-article-id:2637085 N2 - PMID: 18298083 The concept is developed that enzyme mechanisms should be viewed as “catalytic networks” with multiple conformations that occur serially and in parallel in the mechanism. These coupled ensembles of conformations require a multi-dimensional standard free-energy surface that is very “rugged”, containing multiple minima and transition states. Experimental and theoretical evidence is presented to support this concept. IS - 11 JF - Biochemistry AD - Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, and Department of Biochemistry, Box 3711, Duke University, Durham, North Carolina 27710 EP - 3321 TI - Free-Energy Landscape of Enzyme Catalysis† VL - 47 SP - 3317 KW - catalysis KW - dhfr KW - energy_landscape KW - enzyme KW - free-energy AU - Benkovic, Stephen AU - Hammes, Gordon AU - Hammes-Schiffer, Sharon PY - 2008/03/01/ UR - http://dx.doi.org/10.1021/bi800049z ER -