Catabolite activator protein: DNA binding and transcription activation Export

@article{citeulike:3268715, abstract = {Recently determined structures of the Escherichia coli catabolite activator protein (CAP) in complex with DNA, and in complex with the RNA polymerase [alpha] subunit C-terminal domain ([alpha]CTD) and DNA, have yielded insights into how CAP binds DNA and activates transcription. Comparison of multiple structures of CAP-DNA complexes has revealed the contributions of direct and indirect readout to DNA binding by CAP. The structure of the CAP-[alpha]CTD-DNA complex has provided the first structural description of interactions between a transcription activator and its functional target within the general transcription machinery. Using the structure of the CAP-[alpha]CTD-DNA complex, the structure of an RNA polymerase-DNA complex, and restraints from biophysical, biochemical and genetic experiments, it has been possible to construct detailed three-dimensional models of intact class I and class II transcription activation complexes.}, author = {Lawson, Catherine L. and Swigon, David and Murakami, Katsuhiko S. and Darst, Seth A. and Berman, Helen M. and Ebright, Richard H.}, citeulike-article-id = {3268715}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.sbi.2004.01.012}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6VS6-4BJDDF1-1/2/259c6f6191b03e86b4cb019796d7ce4f}, doi = {10.1016/j.sbi.2004.01.012}, journal = {Current Opinion in Structural Biology}, keywords = {allostery, cap, cap\_dna, protein, review}, month = {February}, number = {1}, pages = {10--20}, posted-at = {2008-09-15 10:56:08}, priority = {2}, title = {Catabolite activator protein: DNA binding and transcription activation}, url = {http://dx.doi.org/10.1016/j.sbi.2004.01.012}, volume = {14}, year = {2004} }

TY - JOUR ID - citeulike:3268715 L3 - citeulike-article-id:3268715 N2 - Recently determined structures of the Escherichia coli catabolite activator protein (CAP) in complex with DNA, and in complex with the RNA polymerase [alpha] subunit C-terminal domain ([alpha]CTD) and DNA, have yielded insights into how CAP binds DNA and activates transcription. Comparison of multiple structures of CAP-DNA complexes has revealed the contributions of direct and indirect readout to DNA binding by CAP. The structure of the CAP-[alpha]CTD-DNA complex has provided the first structural description of interactions between a transcription activator and its functional target within the general transcription machinery. Using the structure of the CAP-[alpha]CTD-DNA complex, the structure of an RNA polymerase-DNA complex, and restraints from biophysical, biochemical and genetic experiments, it has been possible to construct detailed three-dimensional models of intact class I and class II transcription activation complexes. IS - 1 JF - Current Opinion in Structural Biology EP - 20 TI - Catabolite activator protein: DNA binding and transcription activation VL - 14 SP - 10 KW - allostery KW - cap KW - cap_dna KW - protein KW - review AU - Lawson, Catherine AU - Swigon, David AU - Murakami, Katsuhiko AU - Darst, Seth AU - Berman, Helen AU - Ebright, Richard PY - 2004/02// UR - http://dx.doi.org/10.1016/j.sbi.2004.01.012 ER -