Eurasian and African mitochondrial DNA influences in the Saudi Arabian population Export

@article{Abu-Amero2007a, abstract = {Background Genetic studies of the Arabian Peninsula are scarce even though the region was the center of ancient trade routes and empires and may have been the southern corridor for the earliest human migration from Africa to Asia. A total of 120 mtDNA Saudi Arab lineages were analyzed for HVSI/II sequences and for haplogroup confirmatory coding diagnostic positions. A phylogeny of the most abundant haplogroup (preHV)1 (R0a) was constructed based on 13 whole mtDNA genomes. Results The Saudi Arabian group showed greatest similarity to other Arabian Peninsula populations (Bedouin from the Negev desert and Yemeni) and to Levantine populations. Nearly all the main western Asia haplogroups were detected in the Saudi sample, including the rare U9 clade. Saudi Arabs had only a minority sub-Saharan Africa component (7\%), similar to the specific North-African contribution (5\%). In addition, a small Indian influence (3\%) was also detected. Conclusion The majority of the Saudi-Arab mitochondrial DNA lineages (85\%) have a western Asia provenance. Although the still large confidence intervals, the coalescence and phylogeography of (preHV)1 haplogroup (accounting for 18 \% of Saudi Arabian lineages) matches a Neolithic expansion in Saudi Arabia.}, author = {Abu-Amero, Khaled K. and Gonzalez, Ana M. and Larruga, Jose M. and Bosley, Thomas M. and Cabrera, Vicente M.}, citeulike-article-id = {1136355}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1471-2148-7-32}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17331239}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17331239}, doi = {10.1186/1471-2148-7-32}, issn = {1471-2148}, journal = {BMC Evolutionary Biology}, keywords = {geographic-variation, haplotype-counting, mt-haplogroup-prehv, mt-haplogroup-u, mtdna, population-history, saudi-arabia, yemen}, month = {March}, pages = {32+}, posted-at = {2007-07-12 13:55:37}, priority = {2}, title = {Eurasian and African mitochondrial DNA influences in the Saudi Arabian population}, url = {http://dx.doi.org/10.1186/1471-2148-7-32}, volume = {7}, year = {2007} }

TY - JOUR ID - Abu-Amero2007a L3 - citeulike-article-id:1136355 N2 - Background Genetic studies of the Arabian Peninsula are scarce even though the region was the center of ancient trade routes and empires and may have been the southern corridor for the earliest human migration from Africa to Asia. A total of 120 mtDNA Saudi Arab lineages were analyzed for HVSI/II sequences and for haplogroup confirmatory coding diagnostic positions. A phylogeny of the most abundant haplogroup (preHV)1 (R0a) was constructed based on 13 whole mtDNA genomes. Results The Saudi Arabian group showed greatest similarity to other Arabian Peninsula populations (Bedouin from the Negev desert and Yemeni) and to Levantine populations. Nearly all the main western Asia haplogroups were detected in the Saudi sample, including the rare U9 clade. Saudi Arabs had only a minority sub-Saharan Africa component (7%), similar to the specific North-African contribution (5%). In addition, a small Indian influence (3%) was also detected. Conclusion The majority of the Saudi-Arab mitochondrial DNA lineages (85%) have a western Asia provenance. Although the still large confidence intervals, the coalescence and phylogeography of (preHV)1 haplogroup (accounting for 18 % of Saudi Arabian lineages) matches a Neolithic expansion in Saudi Arabia. JF - BMC Evolutionary Biology SN - 1471-2148 TI - Eurasian and African mitochondrial DNA influences in the Saudi Arabian population VL - 7 SP - 32 KW - geographic-variation KW - haplotype-counting KW - mt-haplogroup-prehv KW - mt-haplogroup-u KW - mtdna KW - population-history KW - saudi-arabia KW - yemen AU - Abu-Amero, Khaled AU - Gonzalez, Ana AU - Larruga, Jose AU - Bosley, Thomas AU - Cabrera, Vicente PY - 2007/03/01/ UR - http://dx.doi.org/10.1186/1471-2148-7-32 ER -