Implications of biogeography of human populations for 'race' and medicine Export

@article{Tishkoff2004a, abstract = {In this review, we focus on the biogeographical distribution of genetic variation and address whether or not populations cluster according to the popular concept of 'race'. We show that racial classifications are inadequate descriptors of the distribution of genetic variation in our species. Although populations do cluster by broad geographic regions, which generally correspond to socially recognized races, the distribution of genetic variation is quasicontinuous in clinal patterns related to geography. The broad global pattern reflects the accumulation of genetic drift associated with a recent African origin of modern humans, followed by expansion out of Africa and across the rest of the globe. Because disease genes may be geographically restricted due to mutation, genetic drift, migration and natural selection, knowledge of individual ancestry will be important for biomedical studies. Identifiers based on race will often be insufficient.}, author = {Tishkoff, Sarah A. and Kidd, Kenneth K.}, citeulike-article-id = {1416465}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng1438}, doi = {10.1038/ng1438}, journal = {Nature Genetics}, keywords = {africa, disease, geographic-structure, human-origins, out-of-africa, population-structure, pro-replacement, race}, pages = {S21--S27}, posted-at = {2007-06-27 16:20:50}, priority = {0}, title = {Implications of biogeography of human populations for 'race' and medicine}, url = {http://dx.doi.org/10.1038/ng1438}, volume = {36}, year = {2004} }

TY - JOUR ID - Tishkoff2004a L3 - citeulike-article-id:1416465 N2 - In this review, we focus on the biogeographical distribution of genetic variation and address whether or not populations cluster according to the popular concept of 'race'. We show that racial classifications are inadequate descriptors of the distribution of genetic variation in our species. Although populations do cluster by broad geographic regions, which generally correspond to socially recognized races, the distribution of genetic variation is quasicontinuous in clinal patterns related to geography. The broad global pattern reflects the accumulation of genetic drift associated with a recent African origin of modern humans, followed by expansion out of Africa and across the rest of the globe. Because disease genes may be geographically restricted due to mutation, genetic drift, migration and natural selection, knowledge of individual ancestry will be important for biomedical studies. Identifiers based on race will often be insufficient. JF - Nature Genetics EP - S27 TI - Implications of biogeography of human populations for 'race' and medicine VL - 36 SP - S21 KW - africa KW - disease KW - geographic-structure KW - human-origins KW - out-of-africa KW - population-structure KW - pro-replacement KW - race AU - Tishkoff, Sarah AU - Kidd, Kenneth PY - 2004/// UR - http://dx.doi.org/10.1038/ng1438 ER -