Deconstructing Jaco: Genetic Heritage of an Afrikaner Export

@article{Greeff2007a, abstract = {Summary It is often assumed that Afrikaners stem from a small number of Dutch immigrants. As a result they should be genetically homogeneous, show founder effects and be rather inbred. By disentangling my own South African pedigree, that is on average 12 generations deep, I try to quantify the genetic heritage of an Afrikaner. As much as 6\% of my genes have been contributed by slaves from Africa, Madagascar and India, and a woman from China. This figure compares well to other genetic and genealogical estimates. Seventy three percent of my lineages coalesce into common founders, and I am related in excess of 10 times to 20 founder ancestors (30 times to Willem Schalk van der Merwe). Significant founder effects are thus possible. The overrepresentation of certain founder ancestors is in part explained by the fact that they had more children. This is remarkable given that they lived more than 300 years (or 12 generations) ago. DECONSTRUCT, a new program for pedigree analysis, identified 125 common ancestors in my pedigree. However, these common ancestors are so distant from myself, paths of between 16 and 25 steps in length, that my inbreeding coefficient is not unusually high (f \"{U} 0.0019).}, author = {Greeff, J. M.}, citeulike-article-id = {1459825}, citeulike-linkout-0 = {http://www.blackwell-synergy.com/doi/abs/10.1111/j.1469-1809.2007.00363.x}, citeulike-linkout-1 = {http://dx.doi.org/10.1111/j.1469-1809.2007.00363.x}, doi = {10.1111/j.1469-1809.2007.00363.x}, journal = {Annals of Human Genetics}, keywords = {africa, afrikaner, founder-effect, inbreeding, pedigree, relatedness, update-when-published}, number = {0}, pages = {???}, posted-at = {2007-07-16 19:51:51}, priority = {2}, title = {Deconstructing Jaco: Genetic Heritage of an Afrikaner}, url = {http://dx.doi.org/10.1111/j.1469-1809.2007.00363.x}, volume = {0}, year = {0000} }

TY - JOUR ID - Greeff2007a L3 - citeulike-article-id:1459825 N2 - Summary It is often assumed that Afrikaners stem from a small number of Dutch immigrants. As a result they should be genetically homogeneous, show founder effects and be rather inbred. By disentangling my own South African pedigree, that is on average 12 generations deep, I try to quantify the genetic heritage of an Afrikaner. As much as 6% of my genes have been contributed by slaves from Africa, Madagascar and India, and a woman from China. This figure compares well to other genetic and genealogical estimates. Seventy three percent of my lineages coalesce into common founders, and I am related in excess of 10 times to 20 founder ancestors (30 times to Willem Schalk van der Merwe). Significant founder effects are thus possible. The overrepresentation of certain founder ancestors is in part explained by the fact that they had more children. This is remarkable given that they lived more than 300 years (or 12 generations) ago. DECONSTRUCT, a new program for pedigree analysis, identified 125 common ancestors in my pedigree. However, these common ancestors are so distant from myself, paths of between 16 and 25 steps in length, that my inbreeding coefficient is not unusually high (f Ü 0.0019). IS - 0 JF - Annals of Human Genetics EP - ??? TI - Deconstructing Jaco: Genetic Heritage of an Afrikaner VL - 0 SP - ??? KW - africa KW - afrikaner KW - founder-effect KW - inbreeding KW - pedigree KW - relatedness KW - update-when-published AU - Greeff, JM PY - 2000/// UR - http://dx.doi.org/10.1111/j.1469-1809.2007.00363.x ER -