Bacterial population genetics, evolution and epidemiology. Export

@article{Spratt1999a, abstract = {Asexual bacterial populations inevitably consist of an assemblage of distinct clonal lineages. However, bacterial populations are not entirely asexual since recombinational exchanges occur, mobilizing small genome segments among lineages and species. The relative contribution of recombination, as opposed to de novo mutation, in the generation of new bacterial genotypes varies among bacterial populations and, as this contribution increases, the clonality of a given population decreases. In consequence, a spectrum of possible population structures exists, with few bacterial species occupying the extremes of highly clonal and completely non-clonal, most containing both clonal and non-clonal elements. The analysis of collections of bacterial isolates, which accurately represent the natural population, by nucleotide sequence determination of multiple housekeeping loci provides data that can be used both to investigate the population structure of bacterial pathogens and for the molecular characterization of bacterial isolates. Understanding the population structure of a given pathogen is important since it impacts on the questions that can be addressed by, and the methods and samples required for, effective molecular epidemiological studies.}, author = {Spratt, B. G. and Maiden, M. C. J.}, citeulike-article-id = {1530516}, citeulike-linkout-0 = {http://dx.doi.org/10.1098/rstb.1999.0423}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/10365396}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=10365396}, day = {29}, doi = {10.1098/rstb.1999.0423}, issn = {0962-8436}, journal = {Philosophical transactions of the Royal Society of London. Series B, Biological sciences}, keywords = {bacterial-pop-gen}, month = {April}, number = {1384}, pages = {701--710}, posted-at = {2007-08-02 13:23:26}, priority = {2}, title = {Bacterial population genetics, evolution and epidemiology.}, url = {http://dx.doi.org/10.1098/rstb.1999.0423}, volume = {354}, year = {1999} }

TY - JOUR ID - Spratt1999a L3 - citeulike-article-id:1530516 N2 - Asexual bacterial populations inevitably consist of an assemblage of distinct clonal lineages. However, bacterial populations are not entirely asexual since recombinational exchanges occur, mobilizing small genome segments among lineages and species. The relative contribution of recombination, as opposed to de novo mutation, in the generation of new bacterial genotypes varies among bacterial populations and, as this contribution increases, the clonality of a given population decreases. In consequence, a spectrum of possible population structures exists, with few bacterial species occupying the extremes of highly clonal and completely non-clonal, most containing both clonal and non-clonal elements. The analysis of collections of bacterial isolates, which accurately represent the natural population, by nucleotide sequence determination of multiple housekeeping loci provides data that can be used both to investigate the population structure of bacterial pathogens and for the molecular characterization of bacterial isolates. Understanding the population structure of a given pathogen is important since it impacts on the questions that can be addressed by, and the methods and samples required for, effective molecular epidemiological studies. IS - 1384 JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences SN - 0962-8436 EP - 710 TI - Bacterial population genetics, evolution and epidemiology. VL - 354 SP - 701 KW - bacterial-pop-gen AU - Spratt, BG AU - Maiden, MCJ PY - 1999/04/29/ UR - http://dx.doi.org/10.1098/rstb.1999.0423 ER -