Geographically Separate Increases in the Frequency of the Derived ADH1B*47His Allele in Eastern and Western Asia Export

@article{Li2007d, abstract = {The ADH1B Arg47His polymorphism has been convincingly associated with alcoholism in numerous studies of several populations in Asia and Europe. In a review of literature from the past 30 years, we have identified studies that report allele frequencies of this polymorphism for 131 population samples from many different parts of the world. The derived ADH1B*47His allele reaches high frequencies only in western and eastern Asia. To pursue this pattern, we report here new frequency data for 37 populations. Most of our data are from South and Southeast Asia and confirm that there is a low frequency of this allele in the region between eastern and western Asia. The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia.}, author = {Li, Hui and Mukherjee, Namita and Soundararajan, Usha and T\'{a}rnok, Zsanett and Barta, Csaba and Khaliq, Shagufta and Mohyuddin, Aisha and Kajuna, Sylvester L. B. and Mehdi, Qasim S. and Kidd, Judith R. and Kidd, Kenneth K.}, citeulike-article-id = {1595198}, citeulike-linkout-0 = {http://www.journals.uchicago.edu/cgi-bin/resolve?id=doi:10.1086/521201}, citeulike-linkout-1 = {http://dx.doi.org/10.1086/521201}, doi = {10.1086/521201}, journal = {The American Journal of Human Genetics}, keywords = {alcoholism, population-structure, selection, update-when-published}, posted-at = {2007-08-26 22:16:08}, priority = {2}, title = {Geographically Separate Increases in the Frequency of the Derived ADH1B*47His Allele in Eastern and Western Asia}, url = {http://dx.doi.org/10.1086/521201}, volume = {81}, year = {2007} }

TY - JOUR ID - Li2007d L3 - citeulike-article-id:1595198 N2 - The ADH1B Arg47His polymorphism has been convincingly associated with alcoholism in numerous studies of several populations in Asia and Europe. In a review of literature from the past 30 years, we have identified studies that report allele frequencies of this polymorphism for 131 population samples from many different parts of the world. The derived ADH1B*47His allele reaches high frequencies only in western and eastern Asia. To pursue this pattern, we report here new frequency data for 37 populations. Most of our data are from South and Southeast Asia and confirm that there is a low frequency of this allele in the region between eastern and western Asia. The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia. JF - The American Journal of Human Genetics TI - Geographically Separate Increases in the Frequency of the Derived ADH1B*47His Allele in Eastern and Western Asia VL - 81 KW - alcoholism KW - population-structure KW - selection KW - update-when-published AU - Li, Hui AU - Mukherjee, Namita AU - Soundararajan, Usha AU - Tárnok, Zsanett AU - Barta, Csaba AU - Khaliq, Shagufta AU - Mohyuddin, Aisha AU - Kajuna, Sylvester AU - Mehdi, Qasim AU - Kidd, Judith AU - Kidd, Kenneth PY - 2007/// UR - http://dx.doi.org/10.1086/521201 ER -