Contrasting Signatures of Population Growth for Mitochondrial DNA and Y Chromosomes among Human Populations in Africa. Export

@article{citeulike:2180868, abstract = {A history of Pleistocene population expansion has been inferred from the frequency spectrum of polymorphism in the mitochondrial DNA (mtDNA) of many human populations. Similar patterns are not typically observed for autosomal and X-linked loci. One explanation for this discrepancy is a recent population bottleneck, with different rates of recovery for haploid and autosomal loci as a result of their different effective population sizes. This hypothesis predicts that mitochondrial and Y chromosomal DNA will show a similar skew in the frequency spectrum in populations that have experienced a recent increase in effective population size. We test this hypothesis by re-sequencing 6.6 kb of non-coding Y chromosomal DNA and 780 basepairs of the mtDNA cytochrome c oxidase subunit III (COIII) gene in 172 males from five African populations. Four tests of population expansion are employed for each locus in each population: Fu's Fs statistic, the R(2) statistic, coalescent simulations and the mismatch distribution. Consistent with previous results, patterns of mtDNA polymorphism better fit a model of constant population size for food-gathering populations and a model of population expansion for food-producing populations. In contrast, none of the tests reveal evidence of Y chromosome growth for either food-gatherers or food-producers. The distinct mtDNA and Y chromosome polymorphism patterns most likely reflect sex-biased demographic processes in the recent history of African populations. We hypothesize that males experienced smaller effective population sizes and/or lower rates of migration during the Bantu expansion, which occurred over the last five thousand years.}, address = {Department of Anthropology, University of Arizona, Tucson AZ 85721.}, author = {Pilkington, Maya Metni M. and Wilder, Jason A A. and Mendez, Fernando L L. and Cox, Murray P P. and Woerner, August and Angui, Thiep and Kingan, Sarah and Mobasher, Zahra and Batini, Chiara and Destro-Bisol, Giovanni and Soodyall, Himla and Strassmann, Beverly I I. and Hammer, Michael F F.}, citeulike-article-id = {2180868}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/molbev/msm279}, citeulike-linkout-1 = {http://mbe.oxfordjournals.org/cgi/content/abstract/25/3/517}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18093995}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18093995}, day = {18}, doi = {10.1093/molbev/msm279}, issn = {0737-4038}, journal = {Mol Biol Evol}, keywords = {africa, demography, mtdna, to-get, to-review, y-chromosome}, month = {December}, posted-at = {2008-01-10 17:09:28}, priority = {2}, title = {Contrasting Signatures of Population Growth for Mitochondrial DNA and Y Chromosomes among Human Populations in Africa.}, url = {http://dx.doi.org/10.1093/molbev/msm279}, year = {2007} }

TY - JOUR ID - citeulike:2180868 L3 - citeulike-article-id:2180868 N2 - A history of Pleistocene population expansion has been inferred from the frequency spectrum of polymorphism in the mitochondrial DNA (mtDNA) of many human populations. Similar patterns are not typically observed for autosomal and X-linked loci. One explanation for this discrepancy is a recent population bottleneck, with different rates of recovery for haploid and autosomal loci as a result of their different effective population sizes. This hypothesis predicts that mitochondrial and Y chromosomal DNA will show a similar skew in the frequency spectrum in populations that have experienced a recent increase in effective population size. We test this hypothesis by re-sequencing 6.6 kb of non-coding Y chromosomal DNA and 780 basepairs of the mtDNA cytochrome c oxidase subunit III (COIII) gene in 172 males from five African populations. Four tests of population expansion are employed for each locus in each population: Fu's Fs statistic, the R(2) statistic, coalescent simulations and the mismatch distribution. Consistent with previous results, patterns of mtDNA polymorphism better fit a model of constant population size for food-gathering populations and a model of population expansion for food-producing populations. In contrast, none of the tests reveal evidence of Y chromosome growth for either food-gatherers or food-producers. The distinct mtDNA and Y chromosome polymorphism patterns most likely reflect sex-biased demographic processes in the recent history of African populations. We hypothesize that males experienced smaller effective population sizes and/or lower rates of migration during the Bantu expansion, which occurred over the last five thousand years. JF - Mol Biol Evol SN - 0737-4038 AD - Department of Anthropology, University of Arizona, Tucson AZ 85721. TI - Contrasting Signatures of Population Growth for Mitochondrial DNA and Y Chromosomes among Human Populations in Africa. KW - africa KW - demography KW - mtdna KW - to-get KW - to-review KW - y-chromosome AU - Pilkington, Maya Metni AU - Wilder, Jason A AU - Mendez, Fernando L AU - Cox, Murray P AU - Woerner, August AU - Angui, Thiep AU - Kingan, Sarah AU - Mobasher, Zahra AU - Batini, Chiara AU - Destro-Bisol, Giovanni AU - Soodyall, Himla AU - Strassmann, Beverly I AU - Hammer, Michael F PY - 2007/12/18/ UR - http://dx.doi.org/10.1093/molbev/msm279 ER -