Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. Export

@article{citeulike:2729939, abstract = {PURPOSE: The aim of this study was to evaluate the effectiveness and toxicity of carbon ion radiotherapy in chordomas of the skull base. METHODS AND MATERIALS: Between November 1998 and July 2005, a total of 96 patients with chordomas of the skull base have been treated with carbon ion radiation therapy (RT) using the raster scan technique at the Gesellschaft f\"{u}r Schwerionenforschung (GSI) in Darmstadt, Germany. All patients had gross residual tumors. Median total dose was 60 CGE (range, 60-70 CGE) delivered in 20 fractions within 3 weeks. Local control and overall survival rates were calculated using the Kaplan-Meier method. Toxicity was assessed according to the Common Terminology Criteria (CTCAE v.3.0) and the Radiation Therapy Oncology Group (RTOG) / European Organization for Research and Treatment of Cancer (EORTC) score. RESULTS: Mean follow-up was 31 months (range, 3-91 months). Fifteen patients developed local recurrences after carbon ion RT. The actuarial local control rates were 80.6\% and 70.0\% at 3 and 5 years, respectively. Target doses in excess of 60 CGE and primary tumor status were associated with higher local control rates. Overall survival was 91.8\% and 88.5\% at 3 and 5 years, respectively. Late toxicity consisted of optic nerve neuropathy RTOG/EORTC Grade 3 in 4.1\% of the patients and necrosis of a fat plomb in 1 patient. Minor temporal lobe injury (RTOG/EORTC Grade 1-2) occurred in 7 patients (7.2\%). CONCLUSIONS: Carbon ion RT offers an effective treatment option for skull-base chordomas with acceptable toxicity. Doses in excess of 75 CGE with 2 CGE per fraction are likely to increase local control probability.}, address = {Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany.Daniela.Ertner@med.uni-heidelberg.de}, author = {Schulz-Ertner, D. and Karger, C. P. and Feuerhake, A. and Nikoghosyan, A. and Combs, S. E. and J\"{a}kel, O. and Edler, L. and Scholz, M. and Debus, J.}, citeulike-article-id = {2729939}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ijrobp.2006.12.059}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17363188}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17363188}, day = {1}, doi = {10.1016/j.ijrobp.2006.12.059}, issn = {0360-3016}, journal = {International journal of radiation oncology, biology, physics}, keywords = {c-ion, chordoma, clinical, therapy}, month = {June}, number = {2}, pages = {449--457}, posted-at = {2008-04-28 13:58:54}, priority = {4}, title = {Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas.}, url = {http://dx.doi.org/10.1016/j.ijrobp.2006.12.059}, volume = {68}, year = {2007} }

TY - JOUR ID - citeulike:2729939 L3 - citeulike-article-id:2729939 N2 - PURPOSE: The aim of this study was to evaluate the effectiveness and toxicity of carbon ion radiotherapy in chordomas of the skull base. METHODS AND MATERIALS: Between November 1998 and July 2005, a total of 96 patients with chordomas of the skull base have been treated with carbon ion radiation therapy (RT) using the raster scan technique at the Gesellschaft für Schwerionenforschung (GSI) in Darmstadt, Germany. All patients had gross residual tumors. Median total dose was 60 CGE (range, 60-70 CGE) delivered in 20 fractions within 3 weeks. Local control and overall survival rates were calculated using the Kaplan-Meier method. Toxicity was assessed according to the Common Terminology Criteria (CTCAE v.3.0) and the Radiation Therapy Oncology Group (RTOG) / European Organization for Research and Treatment of Cancer (EORTC) score. RESULTS: Mean follow-up was 31 months (range, 3-91 months). Fifteen patients developed local recurrences after carbon ion RT. The actuarial local control rates were 80.6% and 70.0% at 3 and 5 years, respectively. Target doses in excess of 60 CGE and primary tumor status were associated with higher local control rates. Overall survival was 91.8% and 88.5% at 3 and 5 years, respectively. Late toxicity consisted of optic nerve neuropathy RTOG/EORTC Grade 3 in 4.1% of the patients and necrosis of a fat plomb in 1 patient. Minor temporal lobe injury (RTOG/EORTC Grade 1-2) occurred in 7 patients (7.2%). CONCLUSIONS: Carbon ion RT offers an effective treatment option for skull-base chordomas with acceptable toxicity. Doses in excess of 75 CGE with 2 CGE per fraction are likely to increase local control probability. IS - 2 JF - International journal of radiation oncology, biology, physics SN - 0360-3016 AD - Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany.Daniela.Ertner@med.uni-heidelberg.de EP - 457 TI - Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. VL - 68 SP - 449 KW - c-ion KW - chordoma KW - clinical KW - therapy AU - Schulz-Ertner, D AU - Karger, CP AU - Feuerhake, A AU - Nikoghosyan, A AU - Combs, SE AU - Jäkel, O AU - Edler, L AU - Scholz, M AU - Debus, J PY - 2007/06/01/ UR - http://dx.doi.org/10.1016/j.ijrobp.2006.12.059 ER -