Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Export

@article{citeulike:2734698, abstract = {PURPOSE: The irradiation system and biophysical characteristics of carbon beams are examined regarding radiation therapy. METHODS AND MATERIALS: An irradiation system was developed for heavy-ion radiotherapy. Wobbler magnets and a scatterer were used for flattening the radiation field. A patient-positioning system using X ray and image intensifiers was also installed in the irradiation system. The depth-dose distributions of the carbon beams were modified to make a spread-out Bragg peak, which was designed based on the biophysical characteristics of monoenergetic beams. A dosimetry system for heavy-ion radiotherapy was established to deliver heavy-ion doses safely to the patients according to the treatment planning. A carbon beam of 80 keV/microm in the spread-out Bragg peak was found to be equivalent in biological responses to the neutron beam that is produced at cyclotron facility in National Institute Radiological Sciences (NIRS) by bombarding 30-MeV deuteron beam on beryllium target. The fractionation schedule of the NIRS neutron therapy was adapted for the first clinical trials using carbon beams. RESULTS: Carbon beams, 290, 350, and 400 MeV/u, were used for a clinical trial from June of 1994. Over 300 patients have already been treated by this irradiation system by the end of 1997.}, address = {Division of Accelerator Physics and Engineering, National Institute of Radiation Sciences, Chiba, Japan.}, author = {Kanai, T. and Endo, M. and Minohara, S. and Miyahara, N. and Koyama-ito, H. and Tomura, H. and Matsufuji, N. and Futami, Y. and Fukumura, A. and Hiraoka, T. and Furusawa, Y. and Ando, K. and Suzuki, M. and Soga, F. and Kawachi, K.}, citeulike-article-id = {2734698}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10219815}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10219815}, day = {1}, issn = {0360-3016}, journal = {International journal of radiation oncology, biology, physics}, keywords = {c-ion, himac, therapy}, month = {April}, number = {1}, pages = {201--210}, posted-at = {2008-04-29 16:31:10}, priority = {0}, title = {Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10219815}, volume = {44}, year = {1999} }

TY - JOUR ID - citeulike:2734698 L3 - citeulike-article-id:2734698 N2 - PURPOSE: The irradiation system and biophysical characteristics of carbon beams are examined regarding radiation therapy. METHODS AND MATERIALS: An irradiation system was developed for heavy-ion radiotherapy. Wobbler magnets and a scatterer were used for flattening the radiation field. A patient-positioning system using X ray and image intensifiers was also installed in the irradiation system. The depth-dose distributions of the carbon beams were modified to make a spread-out Bragg peak, which was designed based on the biophysical characteristics of monoenergetic beams. A dosimetry system for heavy-ion radiotherapy was established to deliver heavy-ion doses safely to the patients according to the treatment planning. A carbon beam of 80 keV/microm in the spread-out Bragg peak was found to be equivalent in biological responses to the neutron beam that is produced at cyclotron facility in National Institute Radiological Sciences (NIRS) by bombarding 30-MeV deuteron beam on beryllium target. The fractionation schedule of the NIRS neutron therapy was adapted for the first clinical trials using carbon beams. RESULTS: Carbon beams, 290, 350, and 400 MeV/u, were used for a clinical trial from June of 1994. Over 300 patients have already been treated by this irradiation system by the end of 1997. IS - 1 JF - International journal of radiation oncology, biology, physics SN - 0360-3016 AD - Division of Accelerator Physics and Engineering, National Institute of Radiation Sciences, Chiba, Japan. EP - 210 TI - Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. VL - 44 SP - 201 KW - c-ion KW - himac KW - therapy AU - Kanai, T AU - Endo, M AU - Minohara, S AU - Miyahara, N AU - Koyama-ito, H AU - Tomura, H AU - Matsufuji, N AU - Futami, Y AU - Fukumura, A AU - Hiraoka, T AU - Furusawa, Y AU - Ando, K AU - Suzuki, M AU - Soga, F AU - Kawachi, K PY - 1999/04/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/10219815 ER -