Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity. Export

@article{citeulike:2757967, abstract = {The new method of chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization was used to analyze chromosomal damage in peripheral blood mononuclear lymphocytes of patients undergoing radiation treatment for esophageal cancer with high-energy X-rays or accelerated carbon ions at the National Institute of Radiological Sciences (Chiba, Japan). Total number of aberrant cells correlated with radiation field size, but no correlation was found with acute toxicity. A high frequency of complex-type exchanges were also recorded. This aberration type presented a high individual variability, and correlated well with the acute morbidity. Cytogenetic analysis by interphase chromosome painting is proposed as a useful tool for monitoring normal tissue effects during radiotherapy.}, address = {National Institute of Radiological Sciences, 9-1-4 Anagawa, Inage-ku, Chiba, Japan. s\_yamada@nirs.go.jp}, author = {Yamada, S. and Durante, M. and Ando, K. and Furusawa, Y. and Kawata, T. and Majima, H. and Tsujii, H.}, citeulike-article-id = {2757967}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10704745}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10704745}, day = {31}, issn = {0304-3835}, journal = {Cancer letters}, keywords = {aberrations, c-ion, chromosome, complex, himac, lymphocytes, therapy}, month = {March}, number = {2}, pages = {215--221}, posted-at = {2008-05-05 14:54:20}, priority = {0}, title = {Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10704745}, volume = {150}, year = {2000} }

TY - JOUR ID - citeulike:2757967 L3 - citeulike-article-id:2757967 N2 - The new method of chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization was used to analyze chromosomal damage in peripheral blood mononuclear lymphocytes of patients undergoing radiation treatment for esophageal cancer with high-energy X-rays or accelerated carbon ions at the National Institute of Radiological Sciences (Chiba, Japan). Total number of aberrant cells correlated with radiation field size, but no correlation was found with acute toxicity. A high frequency of complex-type exchanges were also recorded. This aberration type presented a high individual variability, and correlated well with the acute morbidity. Cytogenetic analysis by interphase chromosome painting is proposed as a useful tool for monitoring normal tissue effects during radiotherapy. IS - 2 JF - Cancer letters SN - 0304-3835 AD - National Institute of Radiological Sciences, 9-1-4 Anagawa, Inage-ku, Chiba, Japan. s_yamada@nirs.go.jp EP - 221 TI - Complex-type chromosomal exchanges in blood lymphocytes during radiation therapy correlate with acute toxicity. VL - 150 SP - 215 KW - aberrations KW - c-ion KW - chromosome KW - complex KW - himac KW - lymphocytes KW - therapy AU - Yamada, S AU - Durante, M AU - Ando, K AU - Furusawa, Y AU - Kawata, T AU - Majima, H AU - Tsujii, H PY - 2000/03/31/ UR - http://view.ncbi.nlm.nih.gov/pubmed/10704745 ER -