Perspectives on the formation of radiation-induced exchange aberrations. Export

@article{citeulike:2775906, abstract = {Controversy surrounding the proposed mechanism of radiation-induced translocation has existed virtually since the inception of radiation genetics/cytogenetics, some 75 years ago. Chief among these controversies is how close chromosomes have to be to one another at the time of exposure for an exchange to occur. An historically related issue, and one that continues to generate lively debate, is whether both chromosomes participating in an exchange must sustain radiation damage, or whether instead a single damaged site on one chromosome is sufficient. The intent of this paper is to present one person's perspective as we revisit these two long-standing issues, armed with more recent knowledge in three key areas. These include a new-found appreciation for the complexity of chromosome rearrangements; molecular processes of recombination that are likely to be involved; and the architecture of the nucleus regarding the relationship among chromosomes during interphase.}, address = {Department of Radiation Oncology, University of Texas Medical Branch, Galveston, TX 77555-0884, USA. mcornfor@utmb.edu}, author = {Cornforth, M. N.}, citeulike-article-id = {2775906}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.dnarep.2006.05.008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16807139}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16807139}, day = {8}, doi = {10.1016/j.dnarep.2006.05.008}, issn = {1568-7864}, journal = {DNA repair}, keywords = {aberrations, chromosome, formation}, month = {September}, number = {9-10}, pages = {1182--1191}, posted-at = {2008-05-09 14:48:47}, priority = {4}, title = {Perspectives on the formation of radiation-induced exchange aberrations.}, url = {http://dx.doi.org/10.1016/j.dnarep.2006.05.008}, volume = {5}, year = {2006} }

TY - JOUR ID - citeulike:2775906 L3 - citeulike-article-id:2775906 N2 - Controversy surrounding the proposed mechanism of radiation-induced translocation has existed virtually since the inception of radiation genetics/cytogenetics, some 75 years ago. Chief among these controversies is how close chromosomes have to be to one another at the time of exposure for an exchange to occur. An historically related issue, and one that continues to generate lively debate, is whether both chromosomes participating in an exchange must sustain radiation damage, or whether instead a single damaged site on one chromosome is sufficient. The intent of this paper is to present one person's perspective as we revisit these two long-standing issues, armed with more recent knowledge in three key areas. These include a new-found appreciation for the complexity of chromosome rearrangements; molecular processes of recombination that are likely to be involved; and the architecture of the nucleus regarding the relationship among chromosomes during interphase. IS - 9-10 JF - DNA repair SN - 1568-7864 AD - Department of Radiation Oncology, University of Texas Medical Branch, Galveston, TX 77555-0884, USA. mcornfor@utmb.edu EP - 1191 TI - Perspectives on the formation of radiation-induced exchange aberrations. VL - 5 SP - 1182 KW - aberrations KW - chromosome KW - formation AU - Cornforth, MN PY - 2006/09/08/ UR - http://dx.doi.org/10.1016/j.dnarep.2006.05.008 ER -