Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. Export

@article{citeulike:1575465, abstract = {In this report, we show that cross-presentation of self-antigens can lead to the peripheral deletion of autoreactive CD8(+) T cells. We had previously shown that transfer of ovalbumin (OVA)-specific CD8(+) T cells (OT-I cells) into rat insulin promoter-membrane-bound form of OVA transgenic mice, which express the model autoantigen OVA in the proximal tubular cells of the kidneys, the beta cells of the pancreas, the thymus, and the testis of male mice, led to the activation of OT-I cells in the draining lymph nodes. This was due to class I-restricted cross-presentation of exogenous OVA on a bone marrow-derived antigen presenting cell (APC) population. Here, we show that adoptively transferred or thymically derived OT-I cells activated by cross-presentation are deleted from the peripheral pool of recirculating lymphocytes. Such deletion only required antigen recognition on a bone marrow-derived population, suggesting that cells of the professional APC class may be tolerogenic under these circumstances. Our results provide a mechanism by which the immune system can induce CD8(+) T cell tolerance to autoantigens that are expressed outside the recirculation pathway of naive T cells.}, address = {Thymus Biology Unit, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville 3050, Victoria, Australia.}, author = {Kurts, C. and Kosaka, H. and Carbone, F. R. and Miller, J. F. and Heath, W. R.}, citeulike-article-id = {1575465}, citeulike-linkout-0 = {http://dx.doi.org/10.1084/jem.186.2.239}, citeulike-linkout-1 = {http://jem.rupress.org/cgi/content/abstract/186/2/239}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/9221753}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=9221753}, day = {21}, doi = {10.1084/jem.186.2.239}, issn = {0022-1007}, journal = {J Exp Med}, keywords = {autoimmunity, cd8, mhc, t-cells, tolerance}, month = {July}, number = {2}, pages = {239--245}, posted-at = {2009-04-27 04:09:47}, priority = {2}, title = {Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells.}, url = {http://dx.doi.org/10.1084/jem.186.2.239}, volume = {186}, year = {1997} }

TY - JOUR ID - citeulike:1575465 L3 - citeulike-article-id:1575465 N2 - In this report, we show that cross-presentation of self-antigens can lead to the peripheral deletion of autoreactive CD8(+) T cells. We had previously shown that transfer of ovalbumin (OVA)-specific CD8(+) T cells (OT-I cells) into rat insulin promoter-membrane-bound form of OVA transgenic mice, which express the model autoantigen OVA in the proximal tubular cells of the kidneys, the beta cells of the pancreas, the thymus, and the testis of male mice, led to the activation of OT-I cells in the draining lymph nodes. This was due to class I-restricted cross-presentation of exogenous OVA on a bone marrow-derived antigen presenting cell (APC) population. Here, we show that adoptively transferred or thymically derived OT-I cells activated by cross-presentation are deleted from the peripheral pool of recirculating lymphocytes. Such deletion only required antigen recognition on a bone marrow-derived population, suggesting that cells of the professional APC class may be tolerogenic under these circumstances. Our results provide a mechanism by which the immune system can induce CD8(+) T cell tolerance to autoantigens that are expressed outside the recirculation pathway of naive T cells. IS - 2 JF - J Exp Med SN - 0022-1007 AD - Thymus Biology Unit, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville 3050, Victoria, Australia. EP - 245 TI - Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. VL - 186 SP - 239 KW - autoimmunity KW - cd8 KW - mhc KW - t-cells KW - tolerance AU - Kurts, C AU - Kosaka, H AU - Carbone, FR AU - Miller, JF AU - Heath, WR PY - 1997/07/21/ UR - http://dx.doi.org/10.1084/jem.186.2.239 ER -