Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates. Export

@article{Antibodies, abstract = {Immunogenicity can be a major obstacle to successful protein drug therapy. Antidrug antibodies may neutralize therapeutic function, influence pharmacokinetics and, in some cases, lead to severe adverse effects. These effects depend on factors including dose, regimen, delivery route and contaminants, among others. Importantly, immunogenicity is a consideration that is better addressed during preclinical development before complications arise in clinical trials or following licensure. This article will address the development and application of computational tools for immunogenicity assessment of protein therapeutics, and validation of those predictions using peripheral blood from exposed subjects or alternative in vivo methods.}, author = {De Groot, Anne S S. and McMurry, Julie and Moise, Lenny}, citeulike-article-id = {3371422}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.coph.2008.08.002}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18775515}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18775515}, day = {19}, doi = {10.1016/j.coph.2008.08.002}, issn = {1471-4892}, journal = {Current opinion in pharmacology}, keywords = {immunogenicity}, month = {September}, posted-at = {2008-10-03 19:02:30}, priority = {3}, title = {Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates.}, url = {http://dx.doi.org/10.1016/j.coph.2008.08.002}, year = {2008} }

TY - JOUR ID - Antibodies L3 - citeulike-article-id:3371422 N2 - Immunogenicity can be a major obstacle to successful protein drug therapy. Antidrug antibodies may neutralize therapeutic function, influence pharmacokinetics and, in some cases, lead to severe adverse effects. These effects depend on factors including dose, regimen, delivery route and contaminants, among others. Importantly, immunogenicity is a consideration that is better addressed during preclinical development before complications arise in clinical trials or following licensure. This article will address the development and application of computational tools for immunogenicity assessment of protein therapeutics, and validation of those predictions using peripheral blood from exposed subjects or alternative in vivo methods. JF - Current opinion in pharmacology SN - 1471-4892 TI - Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates. KW - immunogenicity AU - De Groot, Anne S AU - McMurry, Julie AU - Moise, Lenny PY - 2008/09/19/ UR - http://dx.doi.org/10.1016/j.coph.2008.08.002 ER -