Interspecies scaling of the monoclonal anti-EGF receptor ior EGF/r3 antibody disposition using allometric paradigm: is it really suitable? Export

@article{citeulike:3417205, abstract = {The pharmacokinetic regularity of the murine monoclonal antibody ior EGF/r3 across mammals was studied using allometry. The allometric relationship between the volume of distribution and body weight (W) across mammalian species was characterized by the power equation V(d)=218.8 W(0.84) (r=0.92), and that for clearance by CL=2.96 W(0.76) (r=0.97, excluding the dog). The complex Dedrick plot of the ior EGF/r3 pharmacokinetic data produced a superimposable profile (r=0.73). However, a 4-fold variation was observed between the expected human ior EGF/r3 clearance and the cancer patients' values, using apolysichron time units. The patients showed clearance values that overreached the prediction, and the neoteny phenomena cannot explain such a difference. The pharmacokinetic data from cancer patients, rather than healthy volunteers, suggested any tumour-associated drug clearance process as a possible determinant of the mentioned underestimation. Finally, the results obtained in this study confirmed the potential use of allometric scaling to obtain more insight into the similarities and/or differences of the ior EGF/r3 disposition behaviour among mammals.}, author = {Ducong\'{e}, J. and Fern\'{a}ndez-S\'{a}nchez, E. and Alvarez, D.}, citeulike-article-id = {3417205}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/bdd.398}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15108220}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15108220}, doi = {10.1002/bdd.398}, issn = {0142-2782}, journal = {Biopharmaceutics \& drug disposition}, keywords = {allometric\_scaling, biologics, pharmacokinetics}, month = {May}, number = {4}, pages = {177--186}, posted-at = {2008-10-16 12:00:39}, priority = {2}, title = {Interspecies scaling of the monoclonal anti-EGF receptor ior EGF/r3 antibody disposition using allometric paradigm: is it really suitable?}, url = {http://dx.doi.org/10.1002/bdd.398}, volume = {25}, year = {2004} }

TY - JOUR ID - citeulike:3417205 L3 - citeulike-article-id:3417205 N2 - The pharmacokinetic regularity of the murine monoclonal antibody ior EGF/r3 across mammals was studied using allometry. The allometric relationship between the volume of distribution and body weight (W) across mammalian species was characterized by the power equation V(d)=218.8 W(0.84) (r=0.92), and that for clearance by CL=2.96 W(0.76) (r=0.97, excluding the dog). The complex Dedrick plot of the ior EGF/r3 pharmacokinetic data produced a superimposable profile (r=0.73). However, a 4-fold variation was observed between the expected human ior EGF/r3 clearance and the cancer patients' values, using apolysichron time units. The patients showed clearance values that overreached the prediction, and the neoteny phenomena cannot explain such a difference. The pharmacokinetic data from cancer patients, rather than healthy volunteers, suggested any tumour-associated drug clearance process as a possible determinant of the mentioned underestimation. Finally, the results obtained in this study confirmed the potential use of allometric scaling to obtain more insight into the similarities and/or differences of the ior EGF/r3 disposition behaviour among mammals. IS - 4 JF - Biopharmaceutics & drug disposition SN - 0142-2782 EP - 186 TI - Interspecies scaling of the monoclonal anti-EGF receptor ior EGF/r3 antibody disposition using allometric paradigm: is it really suitable? VL - 25 SP - 177 KW - allometric_scaling KW - biologics KW - pharmacokinetics AU - Ducongé, J AU - Fernández-Sánchez, E AU - Alvarez, D PY - 2004/05// UR - http://dx.doi.org/10.1002/bdd.398 ER -