The allometric approach for interspecies scaling of pharmacokinetic parameters Export

@article{citeulike:3428796, abstract = {By using the invariant pharmacokinetic time, the superficial differences in concentration-time profiles due to chronological time among different species are removed. Finally, as Boxenbaum (1984) has said \&\#x201c;parameters to be scaled, independent variables, and the mathematical relationships used in the scaling process are all at the discretion of the investigator. There are no proper or improper approaches; the only limitations are those imposed by the investigator.\&\#x201d;}, author = {Ritschel, W.}, citeulike-article-id = {3428796}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/0742-8413(92)90003-P}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/0742-8413(92)90003-P}, doi = {10.1016/0742-8413(92)90003-P}, issn = {03064492}, journal = {Comparative Biochemistry and Physiology Part C: Comparative Pharmacology}, keywords = {allometric\_scaling, pharmacokinetics}, month = {October}, number = {2}, pages = {249--253}, posted-at = {2008-10-19 11:44:24}, priority = {2}, title = {The allometric approach for interspecies scaling of pharmacokinetic parameters}, url = {http://dx.doi.org/10.1016/0742-8413(92)90003-P}, volume = {103}, year = {1992} }

TY - JOUR ID - citeulike:3428796 L3 - citeulike-article-id:3428796 N2 - By using the invariant pharmacokinetic time, the superficial differences in concentration-time profiles due to chronological time among different species are removed. Finally, as Boxenbaum (1984) has said “parameters to be scaled, independent variables, and the mathematical relationships used in the scaling process are all at the discretion of the investigator. There are no proper or improper approaches; the only limitations are those imposed by the investigator.” IS - 2 JF - Comparative Biochemistry and Physiology Part C: Comparative Pharmacology SN - 03064492 EP - 253 TI - The allometric approach for interspecies scaling of pharmacokinetic parameters VL - 103 SP - 249 KW - allometric_scaling KW - pharmacokinetics AU - Ritschel, W PY - 1992/10// UR - http://dx.doi.org/10.1016/0742-8413(92)90003-P ER -