High-density lipoprotein function recent advances. Export

@article{citeulike:4115334, abstract = {Although high-density lipoproteins (HDL) possess many features that contribute to the association between elevated HDL cholesterol and protection from atherosclerosis, these lipoproteins may be modified in certain individuals and/or circumstances to become proinflammatory. The ability of HDL to inhibit or paradoxically to enhance vascular inflammation, lipid oxidation, plaque growth, and thrombosis reflects changes in specific enzyme and protein components. The anti-inflammatory and proinflammatory functional properties of HDL can now be assessed using cell-based and cell-free assays. Acute or chronic systemic inflammation and the metabolic syndrome appear to render HDL proinflammatory. In contrast, statins and experimental agents such as apolipoprotein A-1 mimetics render HDL more anti-inflammatory. Functional characterization of HDL is a promising method for enhanced assessment of cardiovascular risk and effectiveness of risk reduction.}, author = {Ansell, B. J. and Watson, K. E. and Fogelman, A. M. and Navab, M. and Fonarow, G. C.}, citeulike-article-id = {4115334}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jacc.2005.06.080}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16286161}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16286161}, day = {15}, doi = {10.1016/j.jacc.2005.06.080}, issn = {1558-3597}, journal = {Journal of the American College of Cardiology}, keywords = {atherosclerosis, hdl}, month = {November}, number = {10}, pages = {1792--1798}, posted-at = {2009-02-28 12:11:16}, priority = {2}, title = {High-density lipoprotein function recent advances.}, url = {http://dx.doi.org/10.1016/j.jacc.2005.06.080}, volume = {46}, year = {2005} }

TY - JOUR ID - citeulike:4115334 L3 - citeulike-article-id:4115334 N2 - Although high-density lipoproteins (HDL) possess many features that contribute to the association between elevated HDL cholesterol and protection from atherosclerosis, these lipoproteins may be modified in certain individuals and/or circumstances to become proinflammatory. The ability of HDL to inhibit or paradoxically to enhance vascular inflammation, lipid oxidation, plaque growth, and thrombosis reflects changes in specific enzyme and protein components. The anti-inflammatory and proinflammatory functional properties of HDL can now be assessed using cell-based and cell-free assays. Acute or chronic systemic inflammation and the metabolic syndrome appear to render HDL proinflammatory. In contrast, statins and experimental agents such as apolipoprotein A-1 mimetics render HDL more anti-inflammatory. Functional characterization of HDL is a promising method for enhanced assessment of cardiovascular risk and effectiveness of risk reduction. IS - 10 JF - Journal of the American College of Cardiology SN - 1558-3597 EP - 1798 TI - High-density lipoprotein function recent advances. VL - 46 SP - 1792 KW - atherosclerosis KW - hdl AU - Ansell, BJ AU - Watson, KE AU - Fogelman, AM AU - Navab, M AU - Fonarow, GC PY - 2005/11/15/ UR - http://dx.doi.org/10.1016/j.jacc.2005.06.080 ER -