Cutting Edge: A Critical Role of B and T Lymphocyte Attenuator in Peripheral T Cell Tolerance Induction Export

@article{citeulike:4408822, abstract = {T cell activation and tolerance are delicately regulated by costimulatory molecules. Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator for T cell activation, its role in peripheral T cell tolerance induction in vivo has not been addressed. In this study, we generated a novel strain of BTLA-deficient mice and used three different models to characterize the function of BTLA in controlling T cell tolerance. In an oral tolerance model, BTLA-deficient mice were found resistant to the induction of T cell tolerance to an oral Ag. Moreover, compared with wild-type OT-II cells, BTLA-/- OT-II cells were less susceptible to tolerance induction by a high-dose OVA peptide administered i.v. Finally, BTLA-/- OT-I cells caused autoimmune diabetes in RIP-mOVA recipient mice. Our results thus demonstrate an important role for BTLA in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. 10.4049/jimmunol.0803161}, author = {Liu, Xikui and Alexiou, Maria and Martin-Orozco, Natalia and Chung, Yeonseok and Nurieva, Roza I. and Ma, Li and Tian, Qiang and Kollias, George and Lu, Sijie and Graf, Daniel and Dong, Chen}, citeulike-article-id = {4408822}, citeulike-linkout-0 = {http://dx.doi.org/10.4049/jimmunol.0803161}, citeulike-linkout-1 = {http://www.jimmunol.org/cgi/content/abstract/182/8/4516}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19342624}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19342624}, day = {15}, doi = {10.4049/jimmunol.0803161}, journal = {J Immunol}, keywords = {autoimmunity, b-cells, t-cells, tolerance}, month = {April}, number = {8}, pages = {4516--4520}, posted-at = {2009-04-27 04:13:27}, priority = {2}, title = {Cutting Edge: A Critical Role of B and T Lymphocyte Attenuator in Peripheral T Cell Tolerance Induction}, url = {http://dx.doi.org/10.4049/jimmunol.0803161}, volume = {182}, year = {2009} }

TY - JOUR ID - citeulike:4408822 L3 - citeulike-article-id:4408822 N2 - T cell activation and tolerance are delicately regulated by costimulatory molecules. Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator for T cell activation, its role in peripheral T cell tolerance induction in vivo has not been addressed. In this study, we generated a novel strain of BTLA-deficient mice and used three different models to characterize the function of BTLA in controlling T cell tolerance. In an oral tolerance model, BTLA-deficient mice were found resistant to the induction of T cell tolerance to an oral Ag. Moreover, compared with wild-type OT-II cells, BTLA-/- OT-II cells were less susceptible to tolerance induction by a high-dose OVA peptide administered i.v. Finally, BTLA-/- OT-I cells caused autoimmune diabetes in RIP-mOVA recipient mice. Our results thus demonstrate an important role for BTLA in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. 10.4049/jimmunol.0803161 IS - 8 JF - J Immunol EP - 4520 TI - Cutting Edge: A Critical Role of B and T Lymphocyte Attenuator in Peripheral T Cell Tolerance Induction VL - 182 SP - 4516 KW - autoimmunity KW - b-cells KW - t-cells KW - tolerance AU - Liu, Xikui AU - Alexiou, Maria AU - Martin-Orozco, Natalia AU - Chung, Yeonseok AU - Nurieva, Roza AU - Ma, Li AU - Tian, Qiang AU - Kollias, George AU - Lu, Sijie AU - Graf, Daniel AU - Dong, Chen PY - 2009/04/15/ UR - http://dx.doi.org/10.4049/jimmunol.0803161 ER -