Noise Propagation in Gene Networks Export

@article{citeulike:142488, abstract = {Accurately predicting noise propagation in gene networks is crucial for understanding signal fidelity in natural networks and designing noise-tolerant gene circuits. To quantify how noise propagates through gene networks, we measured expression correlations between genes in single cells. We found that noise in a gene was determined by its intrinsic fluctuations, transmitted noise from upstream genes, and global noise affecting all genes. A model was developed that explains the complex behavior exhibited by the correlations and reveals the dominant noise sources. The model successfully predicts the correlations as the network is systematically perturbed. This approach provides a step toward understanding and manipulating noise propagation in more complex gene networks. 10.1126/science.1109090}, author = {Pedraza, Juan M. and van Oudenaarden, Alexander}, citeulike-article-id = {142488}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1109090}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/307/5717/1965}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15790857}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15790857}, citeulike-linkout-4 = {http://www.sciencemag.org/cgi/content/full/307/5717/1965}, day = {25}, doi = {10.1126/science.1109090}, journal = {Science}, keywords = {avano\_lab, expression, gene, genecircuits, geneticnetworks, genevariation, networks, noise, stochastic, syntheticbiology}, month = {March}, number = {5717}, pages = {1965--1969}, posted-at = {2006-08-11 09:49:05}, priority = {2}, title = {Noise Propagation in Gene Networks}, url = {http://dx.doi.org/10.1126/science.1109090}, volume = {307}, year = {2005} }

TY - JOUR ID - citeulike:142488 L3 - citeulike-article-id:142488 N2 - Accurately predicting noise propagation in gene networks is crucial for understanding signal fidelity in natural networks and designing noise-tolerant gene circuits. To quantify how noise propagates through gene networks, we measured expression correlations between genes in single cells. We found that noise in a gene was determined by its intrinsic fluctuations, transmitted noise from upstream genes, and global noise affecting all genes. A model was developed that explains the complex behavior exhibited by the correlations and reveals the dominant noise sources. The model successfully predicts the correlations as the network is systematically perturbed. This approach provides a step toward understanding and manipulating noise propagation in more complex gene networks. 10.1126/science.1109090 IS - 5717 JF - Science EP - 1969 TI - Noise Propagation in Gene Networks VL - 307 SP - 1965 KW - avano_lab KW - expression KW - gene KW - genecircuits KW - geneticnetworks KW - genevariation KW - networks KW - noise KW - stochastic KW - syntheticbiology AU - Pedraza, Juan AU - van Oudenaarden, Alexander PY - 2005/03/25/ UR - http://dx.doi.org/10.1126/science.1109090 ER -