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Modifications of DCDHF single molecule fluorophores to impart water solubility

by: Hui Wang, Zhikuan Lu, Samuel J Lord, WE Moerner, Robert J Twieg
Tetrahedron Letters, Vol. 48, No. 19. (7 May 2007), pp. 3471-3474.


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A series of dicyanomethylenedihydrofuran (DCDHF) fluorophores with different hydrophilic groups were synthesized and their photophysical properties and water solubilities were measured. Significant water solubility was achieved without compromising desirable photophysical properties, permitting applications of these fluorophores in biological systems.


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