Bright Ideas for Chemical Biology Export

@article{citeulike:4369995, abstract = {Small-molecule fluorescent probes embody an essential facet of chemical biology. Although numerous compounds are known, the ensemble of fluorescent probes is based on a modest collection of modular ” core” dyes. The elaboration of these dyes with diverse chemical moieties is enabling the precise interrogation of biochemical and biological systems. The importance of fluorescence-based technologies in chemical biology elicits a necessity to understand the major classes of small-molecule fluorophores. Here, we examine the chemical and photophysical properties of oft-used fluorophores and highlight classic and contemporary examples in which utility has been built upon these scaffolds.}, author = {Lavis, Luke D. and Raines, Ronald T.}, citeulike-article-id = {4369995}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/cb700248m}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/cb700248m}, day = {1}, doi = {10.1021/cb700248m}, journal = {ACS Chemical Biology}, keywords = {fluorophores, reference, review}, month = {March}, number = {3}, pages = {142--155}, posted-at = {2009-04-21 01:57:57}, priority = {2}, title = {Bright Ideas for Chemical Biology}, url = {http://dx.doi.org/10.1021/cb700248m}, volume = {3}, year = {2008} }

TY - JOUR ID - citeulike:4369995 L3 - citeulike-article-id:4369995 N2 - Small-molecule fluorescent probes embody an essential facet of chemical biology. Although numerous compounds are known, the ensemble of fluorescent probes is based on a modest collection of modular “core” dyes. The elaboration of these dyes with diverse chemical moieties is enabling the precise interrogation of biochemical and biological systems. The importance of fluorescence-based technologies in chemical biology elicits a necessity to understand the major classes of small-molecule fluorophores. Here, we examine the chemical and photophysical properties of oft-used fluorophores and highlight classic and contemporary examples in which utility has been built upon these scaffolds. IS - 3 JF - ACS Chemical Biology EP - 155 TI - Bright Ideas for Chemical Biology VL - 3 SP - 142 KW - fluorophores KW - reference KW - review AU - Lavis, Luke AU - Raines, Ronald PY - 2008/03/01/ UR - http://dx.doi.org/10.1021/cb700248m ER -